The Mouse CD106 Monoclonal Antibody (PE/Cyanine7 Conjugated) (M-K-2.7) is a valuable tool for researchers studying CD106, a cell adhesion molecule involved in inflammatory processes and immune response regulation. This antibody, conjugated with PE/Cyanine7 for fluorescence detection, specifically targets CD106 in mouse samples, allowing for precise identification and analysis in flow cytometry and other relevant assays. CD106, also known as VCAM-1 (Vascular Cell Adhesion Molecule 1), is a critical mediator of leukocyte adhesion and transmigration during inflammation, as well as playing a role in tissue repair and immune surveillance. Its expression is upregulated in response to inflammatory stimuli, making it a key molecule in the immune response cascade.
Understanding the function and regulation of CD106 is essential for unravelling its role in various physiological and pathological conditions, including atherosclerosis, autoimmune diseases, and cancer metastasis.By utilizing the Mouse CD106 Monoclonal Antibody (PE/Cyanine7 Conjugated) (M-K-2.7), researchers can delve deeper into the intricate mechanisms involving CD106, paving the way for innovative discoveries and potential therapeutic strategies targeting this molecule in the fields of immunology, inflammation, and disease research.
Product Title:
PE/Cyanine7 Anti-Mouse CD106 Antibody [M/K-2.7]
SKU:
AGEL1176
Size:
25µg, 100µg
Clone No:
M/K-2.7
Synonyms:
Vascular cell adhesion protein 1;Vcam1;V-CAM 1;VCAM-1;CD106;
Host Species:
Rat
Reactivity:
Mouse
Application:
FCM
Isotype:
Rat IgG1, κ
Isotype Control:
PE/Cyanine7 Rat IgG1, κ Isotype Control[HRPN]
Form:
Liquid
Conjugation:
PE/Cyanine 7
Recommended Use:
Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:
Swissprot:
P29533
Gene ID:
22329
Storage Buffer:
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:
Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:
CD106 is a 110 kD glycosylphosphatidylinositol (GPI)-linked transmembrane protein, also known as VCAM-1 and INCAM-110. It is constitutively expressed on bone marrow stromal cells, myeloid progenitors, splenic dendritic cells, activated endothelial cells, as well as some lymphocytes. CD106 expression can be upregulated on endothelial cells by inflammatory cytokines. CD106 is involved in adhesion and acts as a counter-receptor for VLA-4 (α4/β1 integrin) and LPAM-1 (α4/β7 integrin).
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