The Mouse CD106 Monoclonal Antibody PE Conjugated (M/K-2.7) is a valuable tool for researchers studying CD106, also known as VCAM-1, a cell surface adhesion molecule involved in immune responses and inflammation. This monoclonal antibody, conjugated with phycoerythrin (PE), is specifically designed for flow cytometry applications, allowing for the detection and analysis of CD106 expression on various cell types.CD106/V-CAM 1 is a critical mediator of leukocyte adhesion to endothelial cells during inflammation, playing a key role in immune cell recruitment to sites of infection or injury.
Understanding the regulation of CD106 expression and function is essential for unraveling its role in immune responses, inflammatory diseases, and vascular disorders. The Mouse CD106 Monoclonal Antibody PE Conjugated (M/K-2.7) provides researchers with a reliable tool to examine CD106 expression levels and dynamics in different physiological and pathological contexts, facilitating further exploration into the molecular mechanisms underlying immune cell trafficking and inflammatory processes.
Product Title:
PE Anti-Mouse CD106 Antibody [M/K-2.7]
SKU:
AGEL1173
Size:
25µg, 100µg
Clone No:
M/K-2.7
Synonyms:
Vascular cell adhesion protein 1;Vcam1;V-CAM 1;VCAM-1;CD106;
Host Species:
Rat
Reactivity:
Mouse
Application:
FCM
Isotype:
Rat IgG1, κ
Isotype Control:
PE Rat IgG1, κ Isotype Control[HRPN]
Form:
Liquid
Conjugation:
PE
Recommended Use:
Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:
Swissprot:
P29533
Gene ID:
22329
Storage Buffer:
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:
Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:
CD106 is a 110 kD glycosylphosphatidylinositol (GPI)-linked transmembrane protein, also known as VCAM-1 and INCAM-110. It is constitutively expressed on bone marrow stromal cells, myeloid progenitors, splenic dendritic cells, activated endothelial cells, as well as some lymphocytes. CD106 expression can be upregulated on endothelial cells by inflammatory cytokines. CD106 is involved in adhesion and acts as a counter-receptor for VLA-4 (α4/β1 integrin) and LPAM-1 (α4/β7 integrin).
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