PE/Cyanine5 Anti-Mouse CD103 Antibody [M290] (AGEL1157)

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SKU:
AGEL1157
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FC
Reactivity:
Mouse
Host Species:
Rat
Isotype:
IgG2a,k
Clone:
M290
Conjugation:
PE/Cy5
Frequently bought together:

Description

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PE/Cyanine5 Anti-Mouse CD103 Antibody [M290]

The Mouse CD103 Monoclonal Antibody PE-Cyanine5 Conjugated (M290, AGEL1157) from Assay Genie is a cutting-edge tool for researchers studying immune cell markers in mice. This antibody is specifically designed to target CD103, a cell surface protein essential for T cell migration and tissue-resident memory T cell function.CD103, also known as integrin αEβ7, plays a crucial role in immune surveillance and immune reactions at mucosal sites. By binding to CD103, this monoclonal antibody enables precise detection and characterization of CD103-expressing cells in tissues and circulation. The PE-Cyanine5 conjugation provides bright and stable fluorescence for flow cytometry applications, allowing researchers to analyze cellular expression profiles with high sensitivity and accuracy.

This antibody is ideal for investigating immune responses, inflammatory processes, and immune cell trafficking in various experimental models, making it a valuable asset for immunologists, cancer researchers, and those studying autoimmune diseases. With its high specificity and reliability, the Mouse CD103 Monoclonal Antibody PE-Cyanine5 Conjugated (M290, AGEL1157) offers a powerful tool for advancing our understanding of immune cell dynamics and developing novel therapeutic strategies for immune-related disorders in mice.

Product Title:PE/Cyanine5 Anti-Mouse CD103 Antibody [M290]
SKU:AGEL1157
Size:25µg, 100µg
Clone No:M290
Synonyms:Integrin alpha-E;Itgae;Integrin alpha M290;CD103;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:PE/Cyanine5 Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:PE/Cyanine 5
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:Q60677
Gene ID:16407
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD103 is a type I transmembrane glycoprotein known as αE integrin or Integrin αIEL chain. It belongs to the integrin family and is primarily found on intestinal intraepithelial lymphocytes (IEL). CD103 is also expressed on a subpopulation of lamina propria T cells, epithelial dendritic cells, lamina propria-derived dendritic cells, and a small subset of peripheral lymphocytes. T regulatory cells express high level of CD103. The CD103 expression on lymphocytes can be induced upon activation and TGF-β stimulation. In association with integrin β7, CD103 is expressed as αE/β7 heterodimer. Mature CD103 protein can be cleaved into 2 chains, a 150 kD (C-terminal) chain and a 25 kD (N-terminal) chain, which remain linked by disulfide bonds. CD103 binds to E-cadherin and mediates homing of lymphocytes to the intestinal epithelium.

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