PE/Cyanine5.5 Anti-Mouse CD103 Antibody [M290] (AGEL1159)

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SKU:
AGEL1159
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Applications:
FC
Frequently bought together:

Description

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PE/Cyanine5.5 Anti-Mouse CD103 Antibody [M290]

The Mouse CD103 Monoclonal Antibody PE-Cyanine5.5 Conjugated (M290) is a valuable tool for researchers studying immune responses in mouse models. This antibody specifically targets CD103, a cell surface molecule known for its involvement in immune cell migration and tissue residency. By conjugating with PE-Cyanine5.5, this antibody allows for easy detection and analysis of CD103-expressing cells by flow cytometry and other imaging techniques.CD103, also known as integrin alpha E, plays a crucial role in immune surveillance and response within tissues, particularly in mucosal surfaces where it is abundantly expressed on intraepithelial lymphocytes.

Studying CD103 expression and function is essential for understanding immune cell dynamics in various physiological and pathological conditions, including infection, inflammation, and cancer.With the Mouse CD103 Monoclonal Antibody PE-Cyanine5.5 Conjugated (M290), researchers can effectively investigate the role of CD103-expressing cells in immune regulation, immune tolerance, and tissue-specific immunity. This antibody provides a reliable tool for in vitro and in vivo studies, offering insights into the complex interplay between immune cells and tissue environments in mouse models.

Product Title:PE/Cyanine5.5 Anti-Mouse CD103 Antibody [M290]
SKU:AGEL1159
Size:25µg, 100µg
Clone No:M290
Synonyms:Integrin alpha-E;Itgae;Integrin alpha M290;CD103;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:PE/Cyanine5.5 Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:PE/Cyanine 5.5
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:Q60677
Gene ID:16407
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD103 is a type I transmembrane glycoprotein known as αE integrin or Integrin αIEL chain. It belongs to the integrin family and is primarily found on intestinal intraepithelial lymphocytes (IEL). CD103 is also expressed on a subpopulation of lamina propria T cells, epithelial dendritic cells, lamina propria-derived dendritic cells, and a small subset of peripheral lymphocytes. T regulatory cells express high level of CD103. The CD103 expression on lymphocytes can be induced upon activation and TGF-β stimulation. In association with integrin β7, CD103 is expressed as αE/β7 heterodimer. Mature CD103 protein can be cleaved into 2 chains, a 150 kD (C-terminal) chain and a 25 kD (N-terminal) chain, which remain linked by disulfide bonds. CD103 binds to E-cadherin and mediates homing of lymphocytes to the intestinal epithelium.

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