PE Anti-Mouse CD103 Antibody [M290] (AGEL1145)

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SKU:
AGEL1145
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Applications:
FC
Frequently bought together:

Description

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PE Anti-Mouse CD103 Antibody [M290]

The Mouse CD103 Monoclonal Antibody PE-conjugated (M290) is a powerful tool for researchers studying immune responses and cell interactions. This antibody, specifically designed for use in flow cytometry applications, targets the CD103 protein found on the surface of certain immune cells.CD103, also known as integrin alpha E, is involved in cell adhesion and migration in mucosal tissues. Its expression is associated with tissue-resident memory T cells, which play a crucial role in immune surveillance and response at barrier surfaces such as the skin and intestines. By targeting CD103 with this antibody, researchers can investigate the presence and function of these specialized immune cells in different biological contexts.

The PE conjugation of this antibody allows for direct and sensitive detection of CD103-expressing cells by flow cytometry, enabling researchers to analyze immune cell populations with high specificity and precision. With its reliability and specificity, the Mouse CD103 Monoclonal Antibody PE-conjugated (M290) is a valuable tool for exploring the role of CD103 in immunity, inflammation, and host defense mechanisms.

Product Title:PE Anti-Mouse CD103 Antibody [M290]
SKU:AGEL1145
Size:50 Tests, 100 Tests, 200 Tests
Clone No:M290
Synonyms:Integrin alpha-E;Itgae;Integrin alpha M290;CD103;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:PE Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:PE
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:Q60677
Gene ID:16407
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD103 is a type I transmembrane glycoprotein known as αE integrin or Integrin αIEL chain. It belongs to the integrin family and is primarily found on intestinal intraepithelial lymphocytes (IEL). CD103 is also expressed on a subpopulation of lamina propria T cells, epithelial dendritic cells, lamina propria-derived dendritic cells, and a small subset of peripheral lymphocytes. T regulatory cells express high level of CD103. The CD103 expression on lymphocytes can be induced upon activation and TGF-β stimulation. In association with integrin β7, CD103 is expressed as αE/β7 heterodimer. Mature CD103 protein can be cleaved into 2 chains, a 150 kD (C-terminal) chain and a 25 kD (N-terminal) chain, which remain linked by disulfide bonds. CD103 binds to E-cadherin and mediates homing of lymphocytes to the intestinal epithelium.

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