FITC Anti-Mouse CD103 Antibody [M290] (AGEL1153)

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SKU:
AGEL1153
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FC
Reactivity:
Mouse
Host Species:
Rat
Isotype:
IgG2a,k
Clone:
M290
Conjugation:
FITC
Frequently bought together:

Description

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FITC Anti-Mouse CD103 Antibody [M290]

The Mouse CD103 Monoclonal Antibody (FITC Conjugated) M290 is a vital tool for researchers seeking to study CD103, a cell surface molecule with implications in immune responses and tissue resident memory T cells. This antibody, conjugated with FITC for versatile detection capabilities, is specifically designed for use in flow cytometry applications and is highly reactive with mouse samples.CD103, also known as integrin alpha E, plays a crucial role in regulating T cell activation, migration, and retention in tissues. Its expression is associated with immune surveillance, particularly in the context of mucosal immunity and anti-tumor responses. By targeting CD103, researchers can investigate the dynamics of T cell populations within tissues and explore their role in immune surveillance and response to pathogens or cancer.

With its FITC conjugation and specificity for mouse CD103, the M290 antibody enables precise detection and analysis of CD103-expressing cells in various tissues and experimental models. This makes it an invaluable tool for studies focused on understanding the role of CD103 in immune surveillance, inflammation, and anti-tumor immunity. Unlock the potential of CD103 research with the Mouse CD103 Monoclonal Antibody (FITC Conjugated) M290 for comprehensive insights into tissue-resident immune populations.

Product Title:FITC Anti-Mouse CD103 Antibody [M290]
SKU:AGEL1153
Size:25µg, 100µg
Clone No:M290
Synonyms:Integrin alpha-E;Itgae;Integrin alpha M290;CD103;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:FITC Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:FITC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:Q60677
Gene ID:16407
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD103 is a type I transmembrane glycoprotein known as αE integrin or Integrin αIEL chain. It belongs to the integrin family and is primarily found on intestinal intraepithelial lymphocytes (IEL). CD103 is also expressed on a subpopulation of lamina propria T cells, epithelial dendritic cells, lamina propria-derived dendritic cells, and a small subset of peripheral lymphocytes. T regulatory cells express high level of CD103. The CD103 expression on lymphocytes can be induced upon activation and TGF-β stimulation. In association with integrin β7, CD103 is expressed as αE/β7 heterodimer. Mature CD103 protein can be cleaved into 2 chains, a 150 kD (C-terminal) chain and a 25 kD (N-terminal) chain, which remain linked by disulfide bonds. CD103 binds to E-cadherin and mediates homing of lymphocytes to the intestinal epithelium.

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