FITC Anti-Mouse CD103 Antibody [M290] (AGEL0332)

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SKU:
AGEL0332
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Host Species:
Rat
Isotype:
IgG2a
Clone:
M290
Conjugation:
FITC
Applications:
FC
Frequently bought together:

Description

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FITC Anti-Mouse CD103 Antibody [M290]

The Mouse CD103 Monoclonal Antibody (FITC Conjugated) (M290) is a specialized reagent for researchers studying immune responses in mice. This antibody is specifically designed for detecting CD103, a cell surface protein involved in immune regulation and tolerance mechanisms within the body.Raised using state-of-the-art techniques, this monoclonal antibody offers high specificity and sensitivity in recognizing CD103 antigens in mouse samples. The FITC conjugation enhances the detection capabilities of the antibody, making it suitable for flow cytometry and immunofluorescence applications.CD103, also known as integrin alpha-E, is integral for tissue homing of immune cells, particularly in the gut and skin.

It plays a crucial role in the regulation of T cell activation and migration to specific sites in the body. By targeting CD103, researchers can gain insights into immune cell behavior, immune surveillance, and the development of effective immunotherapies.Ideal for immunologists, cell biologists, and researchers focusing on immunotherapy, inflammatory diseases, and autoimmune disorders, this Mouse CD103 Monoclonal Antibody (FITC Conjugated) (M290) offers a powerful tool for investigating the intricate mechanisms of the immune system in murine models. Unlock the potential of your research with this advanced antibody reagent.

Product Title:FITC Anti-Mouse CD103 Antibody [M290]
SKU:AGEL0332
Size:50 Tests, 100 Tests, 200 Tests
Clone No:M290
Synonyms:Integrin alpha-E;Itgae;Integrin alpha M290;CD103;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:FITC Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:FITC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:Q60677
Gene ID:16407
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD103 is a type I transmembrane glycoprotein known as αE integrin or Integrin αIEL chain. It belongs to the integrin family and is primarily found on intestinal intraepithelial lymphocytes (IEL). CD103 is also expressed on a subpopulation of lamina propria T cells, epithelial dendritic cells, lamina propria-derived dendritic cells, and a small subset of peripheral lymphocytes. T regulatory cells express high level of CD103. The CD103 expression on lymphocytes can be induced upon activation and TGF-β stimulation. In association with integrin β7, CD103 is expressed as αE/β7 heterodimer. Mature CD103 protein can be cleaved into 2 chains, a 150 kD (C-terminal) chain and a 25 kD (N-terminal) chain, which remain linked by disulfide bonds. CD103 binds to E-cadherin and mediates homing of lymphocytes to the intestinal epithelium.

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