Mouse BID Recombinant Protein (RPPB2890)

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SKU:
RPPB2890
Product type:
Recombinant Protein
Size:
10ug
Species:
Mouse
Target:
BID
Synonyms:
BH3-interacting domain death agonist
Synonyms:
p22 BID
Synonyms:
BID
Synonyms:
FP497
Source:
Escherichia Coli
Uniprot:
P70444
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Description

Product Name:Mouse BID Recombinant Protein
Product Code:RPPB2890
Size:10µg
Species:Mouse
Target:BID
Synonyms:BH3-interacting domain death agonist, p22 BID, BID, FP497, MGC15319, MGC42355.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless liquid formulation.
Formulation:The Mouse BID protein solution contains 10mM Tris-HCl pH-8, 1mM EDTA and 250mM NaCl.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

BID is a pro-apoptotic Bcl-2 protein having only the BH3 domain. In reaction to apoptotic signaling, BID interacts with another Bcl-2 family of cell death regulators, called Bax, they form a heterodimer resulting to the insertion of Bax into the outer mitochondrial membrane. Bax induces the opening of the mitochondrial voltage-dependent anion channel which lead to the release of cytochrome c and other pro-apoptotic factors from the mitochondria resulting in activation of caspases. BID is a mediator of mitochondrial damage induced by caspase-8 (CASP8). CASP8 cleaves BID, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. The major proteolytic product p15 BID releasea cytochrome c. Isoform 1, Isoform 2 and Isoform 4 induce ice-like proteases and apoptosis while Isoform 3 does not induce apoptosis.

BID Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 1-195 amino acids and having a molecular mass of 22 kDa.

UniProt Protein Function:BID: a pro-apoptotic member of the Bcl-2 superfamily. Targets intracellular membranes and contains a BH3 death domain. Heterodimerizes with either the pro-apoptotic protein BAX or the anti-apoptotic protein BCL2, antagonizing its protective effect. The activity of BID is regulated by Caspase 8-mediated cleavage, exposing the BH3 domain and significantly changing the surface charge and hydrophobicity, causing translocation to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced variants have been found.
UniProt Protein Details:

Protein type:Apoptosis; Mitochondrial

Cellular Component: membrane; mitochondrion; cell; cytoplasm; intracellular; cytosol

Molecular Function:protein binding; ubiquitin protein ligase binding

Biological Process: caspase activation; release of cytochrome c from mitochondria; positive regulation of apoptosis; positive regulation of protein homooligomerization; apoptosis; DNA damage response, signal transduction; regulation of protein oligomerization; regulation of cell proliferation; regulation of apoptosis; positive regulation of protein oligomerization; apoptotic mitochondrial changes; protein targeting to mitochondrion; protein homooligomerization

UniProt Code:P70444
NCBI GenInfo Identifier:88984020
NCBI Gene ID:12122
NCBI Accession:P70444.2
UniProt Secondary Accession:P70444,Q99M39,
UniProt Related Accession:P70444
Molecular Weight:21,952 Da
NCBI Full Name:BH3-interacting domain death agonist
NCBI Synonym Full Names:BH3 interacting domain death agonist
NCBI Official Symbol:Bid  
NCBI Official Synonym Symbols:AI875481; AU022477; 2700049M22Rik  
NCBI Protein Information:BH3-interacting domain death agonist; p22 BID
UniProt Protein Name:BH3-interacting domain death agonist
UniProt Synonym Protein Names:p22 BID; BID
Protein Family:Bidirectional sugar transporter
UniProt Gene Name:Bid  
UniProt Entry Name:BID_MOUSE
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