Mouse APRIL Recombinant Protein (RPPB0065)

(No reviews yet) Write a Review

제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.

주문
SKU:
RPPB0065
Product type:
Recombinant Protein
Size:
20ug
Species:
Mouse
Target:
APRIL
Synonyms:
Tumor necrosis factor ligand superfamily member 13
Synonyms:
A proliferation-inducing ligand
Synonyms:
APRIL
Synonyms:
CD256
Source:
Escherichia Coli
Uniprot:
Q9D777
€0.00
Frequently bought together:

Description

Product Name:Mouse APRIL Recombinant Protein
Product Code:RPPB0065
Size:20µg
Species:Mouse
Target:APRIL
Synonyms:Tumor necrosis factor ligand superfamily member 13, A proliferation-inducing ligand, APRIL, CD256, Tnfsf13, April.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:Lyophilized from a 0.2µm filtered concentrated solution in PBS, pH 7.4, with 0.02 % Tween-20.
Solubility:It is recommended to reconstitute the lyophilized APRIL in sterile 18M-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Stability:Lyophilized APRIL although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution APRIL should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Purity:Greater than 97.0% as determined by Analysis by SDS-PAGE.
Amino Acid Sequence:AVLTQKHKKK HSVLHLVPVN ITSKADSDVT EVMWQPVLRR GRGLEAQGDI VRVWDTGIYL LYSQVLFHDV TFTMGQVVSR EGQGRRETLF RCIRSMPSDP DRAYNSCYSA GVFHLHQGDI ITVKIPRANA KLSLSPHGTF LGFVKL
Biological Activity:Determined by a cell proliferation assay using activated T cells.

APRIL which is a part of the TNF ligand superfamily (TNFSF13) is a type II transmembrane protein. Normally, APRIL expression is low in tissues, but is elevated in numerous types of tumors and transformed cell lines. APRIL stimulates proliferation of tumor cell lines and intensifies tumorigenicity in nude mice.

APRIL Mouse Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 146 amino acids and having a molecular mass of 16.4 kDa. The APRIL is purified by proprietary chromatographic techniques.

UniProt Protein Function:TNFSF13: Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. May be implicated in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes. Belongs to the tumor necrosis factor family. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Cytokine

Cellular Component: extracellular space; membrane; cytoplasm; extracellular region; external side of plasma membrane

Molecular Function:cytokine activity; tumor necrosis factor receptor binding

Biological Process: regulation of immune response; immune system process; immunoglobulin production in mucosal tissue; positive regulation of cell proliferation; positive regulation of germinal center formation; immune response; immunoglobulin mediated immune response; positive regulation of isotype switching to IgA isotypes

UniProt Code:Q9D777
NCBI GenInfo Identifier:21363035
NCBI Gene ID:69583
NCBI Accession:Q9D777.1
UniProt Secondary Accession:Q9D777,Q9ERP1,
UniProt Related Accession:Q9D777
Molecular Weight:26,889 Da
NCBI Full Name:Tumor necrosis factor ligand superfamily member 13
NCBI Synonym Full Names:tumor necrosis factor (ligand) superfamily, member 13
NCBI Official Symbol:Tnfsf13  
NCBI Official Synonym Symbols:April; Tall2; Trdl1; 2310026N09Rik  
NCBI Protein Information:tumor necrosis factor ligand superfamily member 13; a proliferation-inducing ligand
UniProt Protein Name:Tumor necrosis factor ligand superfamily member 13
UniProt Synonym Protein Names:A proliferation-inducing ligand; APRIL; CD_antigen: CD256
UniProt Gene Name:Tnfsf13  
UniProt Entry Name:TNF13_MOUSE
View AllClose

Related Products