Mouse ALK/ACVRL1 Recombinant Protein (RPES3386)
- SKU:
- RPES3386
- Product type:
- Recombinant Protein
- Host species:
- HEK293 Cells
- Reactivity:
- Mouse
Frequently bought together:
Description
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Mouse ALK/ACVRL1 Recombinant Protein
Activin A receptor, type II-like 1 (ACVRL1), also known as ALK-1 (activin receptor-like kinase 1), is an endothelial-specific type I receptor of the TGF-beta (transforming growth factor beta) receptor family of ligands. On ligand binding, a heteromeric receptor complex forms consisting of two type II and two type I transmembrane serine/threonine kinases. ACVRL1 protein is expressed in certain blood vessels of kidney, spleen, heart and intestine, serving as an important role during vascular development. Mutations in ACVRL1 gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2 and vascular disease.
| Product Name: | Mouse ALK/ACVRL1 Recombinant Protein (RPES3386) |
| Product Code: | RPES3386 |
| Size: | 100µg |
| Species: | Mouse |
| Expressed Host: | HEK293 Cells |
| Synonyms: | Serine/threonine-protein kinase receptor R3, SKR3, Activin receptor-like kinase 1, ALK-1, TGF-B superfamily receptor type I, TSR-I, ACVRL1, activin A receptor type II-like 1, activin A receptor |
| Accession: | NP_033742.2 |
| Sequence: | Met 1-Pro 119 |
| Fusion tag: | C-His-Fc |
| Activity: | Measured by its ability to inhibit BMP9-induced alkaline phosphatase production by MC3T3E1 mouse chondrogenic cells. David, L. et al. (2007) Blood 109:1953.The ED50 for this effect is typically 60-300 ng/mL in the presence of 2 ng/mL of recombiant human BMP9. |
| Endotoxin: | <1.0 EU per µg of the protein as determined by the LAL method. |
| Protein Construction: | A DNA sequence encoding the mouse ALK1 (NP_033742.2) precursor (Met 1-Pro 119) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus. |
| Purity: | > 95 % as determined by SDS-PAGE |
| Mol Mass: | 39 kDa |
| AP Mol Mass: | 50-55 kDa |
| Formulation: | Lyophilized from sterile PBS, pH 7.4 |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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