Mouse Activin RIIA/ACVR2A Recombinant Protein (RPES2170)

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SKU:
RPES2170
Product type:
Recombinant Protein
Host species:
HEK293 Cells
Reactivity:
Mouse
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Description

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Mouse Activin RIIA/ACVR2A Recombinant Protein

ACVR2A and ACVR2B are two activin type II receptors. ACVR2A has been shown to interact with INHBA, SYNJ2BP and ACVR1B. The bovine ACVR2A gene encodes a protein of 513 amino acids which is highly homologous (approximately 98% identity) to the rat, mouse, and human ACVR2A proteins. Inactivation of ACVR2A is a common event in prostate cancer cells suggesting it may play an important role in the development of prostate cancer. The ACVR2A gene is a putative tumor suppressor gene that is frequently mutated in microsatellite-unstable colon cancers (MSI-H colon cancers). Frameshift mutation of ACVR2A may contribute to MSI-H colon tumorigenesis via disruption of alternate TGF-beta effector pathways.

Product Name:Mouse Activin RIIA/ACVR2A Recombinant Protein (RPES2170)
Product Code:RPES2170
Size:100µg
Species:Mouse
Expressed Host:HEK293 Cells
Synonyms:ActrIIa,Acvr2,TactrII
Accession:NP_031422.3
Sequence:Met 1-Pro 134
Fusion tag:C-His-Fc
Activity:Measured by its ability to neutralize Activin-mediated inhibition on MPC11 cell proliferation.The ED50 for this effect is typically 20-60 ng/mL in the presence of 10 ng/mL recombinant Activin A.
Endotoxin:<1.0 EU per µg of the protein as determined by the LAL method.
Protein Construction:A DNA sequence encoding the extracellular domain of mouse ACVR2A (NP_031422.3) (Met 1-Pro 134) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.
Purity:> 97 % as determined by SDS-PAGE
Mol Mass:41.4 kDa
AP Mol Mass:55-65 kDa
Formulation:Lyophilized from sterile PBS, pH 7.4
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

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