| UniProt Protein Function: | MOB1A: Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38. Binds STK38 and STK38L. Interacts with LATS1 and LATS2. Forms a tripartite complex with STK38 and STK3/MST2. Adrenal gland, bone marrow, brain, placenta, prostate, salivary gland, skeletal muscle, testis, thymus, thyroid gland, heart, spinal cord, fetal brain and fetal liver. Belongs to the MOB1/phocein family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Protein kinase, regulatory subunit Chromosomal Location of Human Ortholog: 2p13.1 Cellular Component: cytosol Molecular Function:protein binding; metal ion binding |
| NCBI Summary: | The protein encoded by this gene is a component of the Hippo signaling pathway, which controls organ size and tumor growth by enhancing apoptosis. Loss of the encoded protein results in cell proliferation and cancer formation. The encoded protein is also involved in the control of microtubule stability during cytokinesis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015] |
| UniProt Code: | Q9H8S9 |
| NCBI GenInfo Identifier: | 56749356 |
| NCBI Gene ID: | 55233 |
| NCBI Accession: | Q9H8S9.4 |
| UniProt Related Accession: | Q9H8S9 |
| Molecular Weight: | |
| NCBI Full Name: | MOB kinase activator 1A |
| NCBI Synonym Full Names: | MOB kinase activator 1A |
| NCBI Official Symbol: | MOB1A |
| NCBI Official Synonym Symbols: | MOB1; MATS1; Mob4B; C2orf6; MOBK1B; MOBKL1B |
| NCBI Protein Information: | MOB kinase activator 1A |
| UniProt Protein Name: | MOB kinase activator 1A |
| UniProt Synonym Protein Names: | Mob1 alpha; Mob1A; Mob1 homolog 1B; Mps one binder kinase activator-like 1B |
| Protein Family: | MOB kinase activator |
| UniProt Gene Name: | MOB1A |
| UniProt Entry Name: | MOB1A_HUMAN |
