| Background: | Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The encoded protein degrades type IV collagen, fibronectin, fibrinogen, casein, vitronectin, α 1-antitrypsin, α 2-macroglobulin, and insulin-like growth factor-binding protein 1, and activates MMP9 by cleavage. The protein differs from most MMP family members in that it lacks a conserved C-terminal protein domain. |
| Synonyms: | Matrix metallopeptidase 26 |
| UniProt Protein Function: | MMP26: May hydrolyze collagen type IV, fibronectin, fibrinogen, beta-casein, type I gelatin and alpha-1 proteinase inhibitor. Is also able to activate progelatinase B. Belongs to the peptidase M10A family. |
| UniProt Protein Details: | Protein type:Protease; Secreted, signal peptide; Secreted; EC 3.4.24.- Chromosomal Location of Human Ortholog: 11p15 Cellular Component: proteinaceous extracellular matrix Molecular Function:zinc ion binding; metalloendopeptidase activity Biological Process: collagen catabolic process; proteolysis |
| NCBI Summary: | Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The encoded protein degrades type IV collagen, fibronectin, fibrinogen, casein, vitronectin, alpha 1-antitrypsin, alpha 2-macroglobulin, and insulin-like growth factor-binding protein 1, and activates MMP9 by cleavage. The protein differs from most MMP family members in that it lacks a conserved C-terminal protein domain. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9NRE1 |
| NCBI GenInfo Identifier: | 73808266 |
| NCBI Gene ID: | 56547 |
| NCBI Accession: | NP_068573.2 |
| UniProt Secondary Accession: | Q9NRE1,Q3MJ78, Q9GZS2, Q9NR87, |
| UniProt Related Accession: | Q9NRE1 |
| Molecular Weight: | 29,708 Da |
| NCBI Full Name: | matrix metalloproteinase-26 preproprotein |
| NCBI Synonym Full Names: | matrix metallopeptidase 26 |
| NCBI Official Symbol: | MMP26 |
| NCBI Protein Information: | matrix metalloproteinase-26 |
| UniProt Protein Name: | Matrix metalloproteinase-26 |
| UniProt Synonym Protein Names: | Endometase; Matrilysin-2 |
| Protein Family: | Matrix metalloproteinase |
| UniProt Gene Name: | MMP26 |
| UniProt Entry Name: | MMP26_HUMAN |
