| UniProt Protein Function: | MMP2: Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Interacts (via the C-terminal hemopexin-like domains- containing region) with the integrin alpha-V/beta-3; the interaction promotes vascular invasion in angiogenic vessels and melamoma cells. Interacts (via the C-terminal PEX domain) with TIMP2 (via the C-terminal); the interaction inhibits the degradation activity. Interacts with GSK3B. Aspirin appears to inhibit expression. Produced by normal skin fibroblasts. PEX is expressed in a number of tumors including gliomas, breast and prostate. Inhibited by histatin-3 1/24 (histatin-5). Belongs to the peptidase M10A family. |
| UniProt Protein Details: | Protein type:Protease; Secreted; Apoptosis; Cell development/differentiation; EC 3.4.24.24; Secreted, signal peptide; Motility/polarity/chemotaxis Cellular Component: extracellular matrix; proteinaceous extracellular matrix; extracellular space; sarcomere; membrane; mitochondrion; cytoplasm; plasma membrane; extracellular region; nucleus Molecular Function:peptidase activity; zinc ion binding; hydrolase activity; metallopeptidase activity; metal ion binding; metalloendopeptidase activity; fibronectin binding Biological Process: response to drug; cell migration; intramembranous ossification; positive regulation of apoptosis; tissue remodeling; negative regulation of cell adhesion; proteolysis; axon regeneration in the peripheral nervous system; blood vessel maturation; negative regulation of vasoconstriction; collagen catabolic process; response to hydrogen peroxide; ovarian follicle development; response to estrogen stimulus; skeletal morphogenesis; response to mechanical stimulus; positive regulation of innate immune response; response to hypoxia; response to oxidative stress; angiogenesis; embryo implantation; positive regulation of cell migration |
| UniProt Code: | P33434 |
| NCBI GenInfo Identifier: | 461766 |
| NCBI Gene ID: | 17390 |
| NCBI Accession: | P33434.1 |
| UniProt Related Accession: | P33434 |
| Molecular Weight: | 65,883 Da |
| NCBI Full Name: | 72 kDa type IV collagenase |
| NCBI Synonym Full Names: | matrix metallopeptidase 2 |
| NCBI Official Symbol: | Mmp2 |
| NCBI Official Synonym Symbols: | GelA; Clg4a; MMP-2 |
| NCBI Protein Information: | 72 kDa type IV collagenase; gelatinase A; 72kD gelatinase; 72kDa gelatinase; 72 kDa gelatinase; 72kD type IV collagenase; 72kDa type IV collagenase; matrix metalloproteinase 2; matrix metalloproteinase-2 |
| UniProt Protein Name: | 72 kDa type IV collagenase |
| UniProt Synonym Protein Names: | 72 kDa gelatinase; Gelatinase A; Matrix metalloproteinase-2; MMP-2 |
| Protein Family: | Matrix metalloproteinase |
| UniProt Gene Name: | Mmp2 |
| UniProt Entry Name: | MMP2_MOUSE |
