| UniProt Protein Function: | Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues. |
| NCBI Summary: | plays important roles in wound healing, angiogenesis, platelet aggregation, and tumor metastasis; mediates the response of the intrinsic glomerular mesangial cell to inflammatory stimuli [RGD, Feb 2006] |
| UniProt Code: | P33436 |
| NCBI GenInfo Identifier: | 146345459 |
| NCBI Gene ID: | 81686 |
| NCBI Accession: | P33436.2 |
| UniProt Secondary Accession: | P33436,P97581, Q6GMM9, |
| UniProt Related Accession: | P33436 |
| Molecular Weight: | 74,149 Da |
| NCBI Full Name: | 72 kDa type IV collagenase |
| NCBI Synonym Full Names: | matrix metallopeptidase 2 |
| NCBI Official Symbol: | Mmp2 |
| NCBI Protein Information: | 72 kDa type IV collagenase; MMP-2; gelatinase A; 72 kDa gelatinase; matrix metalloproteinase 2; matrix metalloproteinase-2 |
| UniProt Protein Name: | 72 kDa type IV collagenase |
| UniProt Synonym Protein Names: | 72 kDa gelatinase; Gelatinase A; Matrix metalloproteinase-2; MMP-2 |
| Protein Family: | Matrix metalloproteinase |
| UniProt Gene Name: | Mmp2 |
| UniProt Entry Name: | MMP2_RAT |
