MMP15 Antibody (PACO14711)
- SKU:
- PACO14711
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | MMP15 Antibody (PACO14711) |
| Antibody SKU: | PACO14711 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:1000-1:5000, WB:1:200-1:1000 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Fusion protein of human MMP15 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse heart tissue, Primary antibody: PACO14711(MMP15 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 90 seconds. |
| Background: | Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. |
| Synonyms: | matrix metallopeptidase 15 (membrane-inserted) |
| UniProt Protein Function: | MMP15: Endopeptidase that degrades various components of the extracellular matrix. May activate progelatinase A. Belongs to the peptidase M10A family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; EC 3.4.24.-; Protease Chromosomal Location of Human Ortholog: 16q13 Cellular Component: plasma membrane Molecular Function:enzyme activator activity; protein binding; serine-type endopeptidase activity Biological Process: collagen catabolic process; extracellular matrix disassembly; protein modification process |
| NCBI Summary: | This gene encodes a member of the peptidase M10 family and membrane-type subfamily of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Members of this subfamily contain a transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. The encoded preproprotein is proteolytically processed to generate the mature protease. This protein may play a role in cancer progression. [provided by RefSeq, Jan 2016] |
| UniProt Code: | P51511 |
| NCBI GenInfo Identifier: | 1705988 |
| NCBI Gene ID: | 4324 |
| NCBI Accession: | P51511.1 |
| UniProt Secondary Accession: | P51511,Q14111, A0A2U6, |
| UniProt Related Accession: | P51511 |
| Molecular Weight: | 75,807 Da |
| NCBI Full Name: | Matrix metalloproteinase-15 |
| NCBI Synonym Full Names: | matrix metallopeptidase 15 |
| NCBI Official Symbol: | MMP15 |
| NCBI Official Synonym Symbols: | MMP-15; MT2MMP; MTMMP2; SMCP-2; MT2-MMP |
| NCBI Protein Information: | matrix metalloproteinase-15 |
| UniProt Protein Name: | Matrix metalloproteinase-15 |
| UniProt Synonym Protein Names: | Membrane-type matrix metalloproteinase 2; MT-MMP 2; MTMMP2; Membrane-type-2 matrix metalloproteinase; MT2-MMP; MT2MMP; SMCP-2 |
| Protein Family: | Matrix metalloproteinase |
| UniProt Gene Name: | MMP15 |
| UniProt Entry Name: | MMP15_HUMAN |
| Antibodies | ELISA Kits |
| Cleaved-MMP15 (Y132) Antibody (PACO00034) | Human MMP15 (Matrix metalloproteinase-15) ELISA Kit (HUFI05076) |
| MMP15 Antibody (PACO04348) | MMP-15 Colorimetric Cell-Based ELISA Kit |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
Related Products
Human MMP15 (Matrix metalloproteinase-15) ELISA Kit (HUFI05076)
