MGLL Antibody (PACO44269)
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주문- SKU:
- PACO44269
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | MGLL Antibody (PACO44269) |
Antibody SKU: | PACO44269 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Monoglyceride lipase protein (1-303AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry of paraffin-embedded human liver cancer using PACO44269 at dilution of 1:100. |
![]() | Immunohistochemistry of paraffin-embedded human kidney tissue using PACO44269 at dilution of 1:100. |
Background: | Converts monoacylglycerides to free fatty acid, and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain (By similarity). Regulates the levels of fatty acid, that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth. |
Synonyms: | Monoglyceride lipase (MGL) (EC 3.1.1.23) (HU-K5) (Lysophospholipase homolog) (Lysophospholipase-like) (Monoacylglycerol lipase) (MAGL), MGLL |
UniProt Protein Function: | MGLL: Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain. Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth. Belongs to the AB hydrolase superfamily. Monoacylglycerol lipase family. |
UniProt Protein Details: | Protein type:Phospholipase; EC 3.1.1.23; Lipid Metabolism - glycerolipid Chromosomal Location of Human Ortholog: 3q21.3 Cellular Component: nucleoplasm; endoplasmic reticulum membrane; extrinsic to membrane; plasma membrane; synapse; cytosol Molecular Function:protein homodimerization activity; acylglycerol lipase activity; lipid binding; lysophospholipase activity Biological Process: platelet activation; glycerophospholipid biosynthetic process; regulation of signal transduction; regulation of axon extension; phospholipid metabolic process; triacylglycerol catabolic process; regulation of inflammatory response; arachidonic acid metabolic process; lipid metabolic process; regulation of sensory perception of pain; inflammatory response; blood coagulation; fatty acid biosynthetic process; acylglycerol catabolic process |
NCBI Summary: | This gene encodes a serine hydrolase of the AB hydrolase superfamily that catalyzes the conversion of monoacylglycerides to free fatty acids and glycerol. The encoded protein plays a critical role in several physiological processes including pain and nociperception through hydrolysis of the endocannabinoid 2-arachidonoylglycerol. Expression of this gene may play a role in cancer tumorigenesis and metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012] |
UniProt Code: | Q99685 |
NCBI GenInfo Identifier: | 47117287 |
NCBI Gene ID: | 11343 |
NCBI Accession: | Q99685.2 |
UniProt Secondary Accession: | Q99685,Q6IBG9, Q96AA5, B3KRC2, B7Z9D1, |
UniProt Related Accession: | Q99685 |
Molecular Weight: | 303 |
NCBI Full Name: | Monoglyceride lipase |
NCBI Synonym Full Names: | monoglyceride lipase |
NCBI Official Symbol: | MGLL |
NCBI Official Synonym Symbols: | MGL; HUK5; MAGL; HU-K5 |
NCBI Protein Information: | monoglyceride lipase; monoacylglycerol lipase; lysophospholipase homolog |
UniProt Protein Name: | Monoglyceride lipase |
UniProt Synonym Protein Names: | HU-K5; Lysophospholipase homolog; Lysophospholipase-like; Monoacylglycerol lipase; MAGL |
Protein Family: | Monoglyceride lipase |
UniProt Gene Name: | MGLL |
UniProt Entry Name: | MGLL_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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