MACC1 Antibody (PACO07500)
- SKU:
- PACO07500
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | MACC1 Antibody (PACO07500) |
| Antibody SKU: | PACO07500 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Metastasis-associated in colon cancer protein 1 protein |
| Form: | Liquid |
| Storage Buffer: | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
| Purification Method: | Antigen Affinity purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Background: | Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumor growth and metastasis in vivo. |
| Synonyms: | SH3 domain-containing protein 7a5,MACC1 |
| UniProt Protein Function: | MACC1: Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumor growth and metastasis in vivo. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 7p21.1 Cellular Component: cytoplasm; nucleus Molecular Function:growth factor activity Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent; positive regulation of cell division |
| NCBI Summary: | MACC1 is a key regulator of the hepatocyte growth factor (HGF; MIM 142409)-HGF receptor (HGFR, or MET; MIM 164860) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 in colon cancer (MIM 114500) specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival (Stein et al., 2009 [PubMed 19098908]).[supplied by OMIM, Mar 2009] |
| UniProt Code: | Q6ZN28 |
| NCBI GenInfo Identifier: | 157502191 |
| NCBI Gene ID: | 346389 |
| NCBI Accession: | NP_877439.3 |
| UniProt Secondary Accession: | Q6ZN28,Q6ZQN8, Q7Z5A5, A8MUS5, B2RNR9, |
| UniProt Related Accession: | Q6ZN28 |
| Molecular Weight: | 96,639 Da |
| NCBI Full Name: | metastasis-associated in colon cancer protein 1 |
| NCBI Synonym Full Names: | metastasis associated in colon cancer 1 |
| NCBI Official Symbol: | MACC1 |
| NCBI Official Synonym Symbols: | 7A5; SH3BP4L |
| NCBI Protein Information: | metastasis-associated in colon cancer protein 1; putative binding protein 7a5; SH3 domain-containing protein 7a5 |
| UniProt Protein Name: | Metastasis-associated in colon cancer protein 1 |
| UniProt Synonym Protein Names: | SH3 domain-containing protein 7a5 |
| Protein Family: | Metastasis-associated in colon cancer protein |
| UniProt Gene Name: | MACC1 |
| UniProt Entry Name: | MACC1_HUMAN |
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