MACC1 Antibody (PACO01992)
- SKU:
- PACO01992
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | MACC1 Antibody |
Antibody SKU: | PACO01992 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | WB:1:500-1:2000 |
Species Reactivity: | Human, Mouse |
Immunogen: | synthesized peptide derived from the Internal region of human MACC1. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | MACC1; Metastasis-associated in colon cancer protein 1; SH3 domain-containing protein 7a5 |
UniProt Protein Function: | MACC1: Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumor growth and metastasis in vivo. |
UniProt Protein Details: | Chromosomal Location of Human Ortholog: 7p21.1 Cellular Component: cytoplasm; nucleus Molecular Function:growth factor activity Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent; positive regulation of cell division |
NCBI Summary: | MACC1 is a key regulator of the hepatocyte growth factor (HGF; MIM 142409)-HGF receptor (HGFR, or MET; MIM 164860) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 in colon cancer (MIM 114500) specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival (Stein et al., 2009 [PubMed 19098908]).[supplied by OMIM, Mar 2009] |
UniProt Code: | Q6ZN28 |
NCBI GenInfo Identifier: | 157502191 |
NCBI Gene ID: | 346389 |
NCBI Accession: | NP_877439.3 |
UniProt Secondary Accession: | Q6ZN28,Q6ZQN8, Q7Z5A5, A8MUS5, B2RNR9, |
UniProt Related Accession: | Q6ZN28 |
Molecular Weight: | 96,639 Da |
NCBI Full Name: | metastasis-associated in colon cancer protein 1 |
NCBI Synonym Full Names: | metastasis associated in colon cancer 1 |
NCBI Official Symbol: | MACC1 |
NCBI Official Synonym Symbols: | 7A5; SH3BP4L |
NCBI Protein Information: | metastasis-associated in colon cancer protein 1; putative binding protein 7a5; SH3 domain-containing protein 7a5 |
UniProt Protein Name: | Metastasis-associated in colon cancer protein 1 |
UniProt Synonym Protein Names: | SH3 domain-containing protein 7a5 |
Protein Family: | Metastasis-associated in colon cancer protein |
UniProt Gene Name: | MACC1 |
UniProt Entry Name: | MACC1_HUMAN |