LMP2 Antibody (PACO52150)
- SKU:
- PACO52150
- Product type:
- Antibody
- Reactivity:
- Epstein-Barr virus
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | LMP2 Antibody (PACO52150) |
| Antibody SKU: | PACO52150 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:200-1:2000 |
| Species Reactivity: | Epstein-Barr virus |
| Immunogen: | Recombinant Epstein-Barr virus Latent membrane protein 2 protein (1-147AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: Mouse liver tissue, Mouse kidney tissue. All lanes: LMP2 antibody at 2µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 54, 41 kDa. Observed band size: 54 kDa. |
| Background: | Isoform LMP2A maintains EBV latent infection of B-lymphocyte, by preventing lytic reactivation of the virus in response to surface immunoglobulin (sIg) cross-linking. Acts like a dominant negative inhibitor of the sIg-associated protein tyrosine kinases, LYN and SYK. Also blocks translocation of the B-cell antigen receptor (BCR) into lipid rafts, preventing the subsequent signaling and accelerated internalization of the BCR upon BCR cross-linking. Serves as a molecular scaffold to recruit SYK, LYN and E3 protein-ubiquitin ligases, such as ITCH and NEDD4L, leading to ubiquitination and potential degradation of both tyrosines kinases. Possesses a constitutive signaling activity in non-transformed cells, inducing bypass of normal B lymphocyte developmental checkpoints allowing immunoglobulin-negative cells to colonize peripheral lymphoid organs. |
| Synonyms: | Latent membrane protein 2 (Terminal protein), LMP2 |
| UniProt Protein Function: | Function: Isoform LMP2A maintains EBV latent infection of B-lymphocyte, by preventing lytic reactivation of the virus in response to surface immunoglobulin (sIg) cross-linking. Acts like a dominant negative inhibitor of the sIg-associated protein tyrosine kinases, LYN and SYK. Also blocks translocation of the B-cell antigen receptor (BCR) into lipid rafts, preventing the subsequent signaling and accelerated internalization of the BCR upon BCR cross-linking. Serves as a molecular scaffold to recruit SYK, LYN and E3 protein-ubiquitin ligases, such as ITCH and NEDD4L, leading to ubiquitination and potential degradation of both tyrosines kinases. Possesses a constitutive signaling activity in non-transformed cells, inducing bypass of normal B lymphocyte developmental checkpoints allowing immunoglobulin-negative cells to colonize peripheral lymphoid organs. Ref.5 Ref.8Isoform LMP2B may be a negative regulator of isoform LMP2A. Ref.5 Ref.8Subunit structure: Isoform LMP2A cytoplasmic N-terminal domain interacts with human SRC family protein tyrosine kinases SYK and LYN. Binds human ITCH, WWP2 and NEDD4L. Ref.6 Ref.9Subcellular location: Isoform LMP2A: Host cell membrane; Multi-pass membrane protein. Note: Isoform LMP2A is localized in plasma membrane lipid rafts. Ref.10 Ref.11Isoform LMP2B: Host endomembrane system; Multi-pass membrane protein. Host cytoplasm › host perinuclear region. Note: Isoform LMP2B localizes to perinuclear regions. Ref.10 Ref.11Post-translational modification: Isoform LMP2A is phosphorylated on cytoplasmic N-terminal tyrosines residues, possibly by human LYN. Ref.4Can be ubiquitinated by human ITCH and WWP2 on the N-terminus in a lysine-independent manner.Miscellaneous: In healthy individuals, EBV typically establishes a persistent latent infection in which the virus can be detected in resting, nonproliferating peripheral B-lymphocytes. These latently infected cells express only 2 virally encoded genes, LMP2A and EBNA1.Sequence similarities: Belongs to the herpesviridae LMP-2 family. |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | P13285 |
| NCBI GenInfo Identifier: | 82503189 |
| NCBI Gene ID: | 3783751 |
| NCBI Accession: | YP_401631.1 |
| UniProt Secondary Accession: | P13285,Q777H4, Q8AZK9 |
| UniProt Related Accession: | P13285,1405236A |
| Molecular Weight: | 17.6 kDa |
| NCBI Full Name: | K15 |
| NCBI Synonym Full Names: | |
| NCBI Official Symbol: | LMP-2A |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | K15; LMP-2A |
| UniProt Protein Name: | Latent membrane protein 2 |
| UniProt Synonym Protein Names: | Terminal protein |
| Protein Family: | Latent membrane protein |
| UniProt Gene Name: | LMP2 |
| UniProt Entry Name: | LMP2_EBVB9 |
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