KRT17 Antibody (PACO27853)
- SKU:
- PACO27853
- Product type:
- Antibody
- Reactivity:
- Bovine
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | KRT17 Antibody (PACO27853) |
| Antibody SKU: | PACO27853 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA |
| Recommended Dilutions: | |
| Species Reactivity: | Bovine |
| Immunogen: | Recombinant Bovine Keratin, type I cytoskeletal 17 protein (1-441AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Background: | Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-α in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors. May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. |
| Synonyms: | Keratin, type I cytoskeletal 17 (Cytokeratin-17) (CK-17) (Keratin-17) (K17), KRT17 |
| UniProt Protein Function: | Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors. May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | A1L595 |
| NCBI GenInfo Identifier: | 157427776 |
| NCBI Gene ID: | 281889 |
| NCBI Accession: | NP_001098792.1 |
| UniProt Secondary Accession: | A1L595,A5PJJ6 |
| UniProt Related Accession: | A1L595 |
| Molecular Weight: | 64.7 kDa |
| NCBI Full Name: | keratin, type I cytoskeletal 17 |
| NCBI Synonym Full Names: | |
| NCBI Official Symbol: | KRT17 |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | keratin, type I cytoskeletal 17 |
| UniProt Protein Name: | Keratin, type I cytoskeletal 17 |
| UniProt Synonym Protein Names: | Cytokeratin-17; CK-17; Keratin-17; K17 |
| Protein Family: | Keratin |
| UniProt Gene Name: | KRT17 |
| UniProt Entry Name: | K1C17_BOVIN |
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