IRAK3 Antibody (PACO14600)
- SKU:
- PACO14600
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
| Antibody Name: | IRAK3 Antibody (PACO14600) |
| Antibody SKU: | PACO14600 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:2000, IHC:1:25-1:100 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Fusion protein of human IRAK3 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO14600(IRAK3 Antibody) at dilution 1/45, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. |
| Synonyms: | interleukin-1 receptor-associated kinase 3 |
| UniProt Protein Function: | IRAK3: a TKL kinase of the IRAK family. The interleukin-1 receptor-associated kinases are important mediators in the signal transduction of Toll-like receptor and IL1R family members, collectively referred to as TIRs. |
| UniProt Protein Details: | Protein type:Kinase, protein; EC 2.7.11.1; Protein kinase, TKL; Protein kinase, Ser/Thr (non-receptor); TKL group; IRAK family Chromosomal Location of Human Ortholog: 12q14.3 Cellular Component: interleukin-1 receptor complex; cytoplasm; nucleus Molecular Function:protein serine/threonine kinase activity; protein homodimerization activity; protein heterodimerization activity; magnesium ion binding; ATP binding Biological Process: negative regulation of MAP kinase activity; negative regulation of interleukin-12 production; regulation of protein complex disassembly; protein amino acid autophosphorylation; cytokine and chemokine mediated signaling pathway; response to virus; response to lipopolysaccharide; negative regulation of tumor necrosis factor production; protein amino acid phosphorylation; activation of NF-kappaB transcription factor; MyD88-dependent toll-like receptor signaling pathway; response to exogenous dsRNA; negative regulation of innate immune response; inhibition of NF-kappaB transcription factor; response to peptidoglycan; negative regulation of toll-like receptor signaling pathway; negative regulation of interleukin-6 production; toll-like receptor signaling pathway; negative regulation of cytokine and chemokine mediated signaling pathway; negative regulation of protein catabolic process; negative regulation of protein complex disassembly Disease: Asthma-related Traits, Susceptibility To, 5 |
| NCBI Summary: | This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010] |
| UniProt Code: | Q9Y616 |
| NCBI GenInfo Identifier: | 322510038 |
| NCBI Gene ID: | 11213 |
| NCBI Accession: | Q9Y616.2 |
| UniProt Secondary Accession: | Q9Y616,B4DQ57, |
| UniProt Related Accession: | Q9Y616 |
| Molecular Weight: | 596 |
| NCBI Full Name: | Interleukin-1 receptor-associated kinase 3 |
| NCBI Synonym Full Names: | interleukin-1 receptor-associated kinase 3 |
| NCBI Official Symbol: | IRAK3 |
| NCBI Official Synonym Symbols: | ASRT5; IRAKM |
| NCBI Protein Information: | interleukin-1 receptor-associated kinase 3; IRAK3; IL-1 receptor-associated kinase M |
| UniProt Protein Name: | Interleukin-1 receptor-associated kinase 3 |
| UniProt Synonym Protein Names: | IL-1 receptor-associated kinase M; IRAK-M |
| Protein Family: | Interleukin-1 receptor-associated kinase |
| UniProt Gene Name: | IRAK3 |
| UniProt Entry Name: | IRAK3_HUMAN |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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