Interleukin-2/IL-2 Recombinant Protein (Mutant) (RPES1629)
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- SKU:
- RPES1629
- Product type:
- Recombinant Protein
- Host species:
- Human Cells
- Reactivity:
- Human
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Description
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Interleukin-2/IL-2 Recombinant Protein (Mutant)
Interleukin-2(IL-2) is an interleukin; a type of cytokine signaling molecule in the immune system;belongs to the IL-2 family. It is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions that are essential for the immune response. IL-2 stimulates growth and differentiation of B-cells; NK cells; lymphokine-activated killer cells; monocytes; macrophages and oligodendrocytes. New research has shown that IL-2 mutant reduced toxicity while being more potent at stimulating anti-tumor effector immune cells.
| Product Name: | Interleukin-2/IL-2 Recombinant Protein (Mutant) (RPES1629) |
| Product Code: | RPES1629 |
| Size: | 10µg |
| Species: | Human |
| Expressed Host: | Human Cells |
| Synonyms: | Interleukin-2, IL-2, T-Cell Growth Factor, TCGF, Aldesleukin, IL3 |
| Accession: | P60568 |
| Sequence: | Ala21-Thr153(L100F;R101D;L105V;I106V;I112F) |
| Activity: | Measured in a cell proliferation assay using CTLL?2 mouse cytotoxic T cells. The specific activity of Recombinant Human IL-2 is ?1×107 IU/mg. |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Human Interleukin-2 is produced by our Mammalian expression system and the target gene encoding Ala21-Thr153(L100F;R101D;L105V;I106V;I112F) is expressed with a 6His tag at the C-terminus. |
| Purity: | > 95% as determined by reducing SDS-PAGE. |
| Mol Mass: | 16.5 kDa |
| AP Mol Mass: | 16&18 kDa |
| Formulation: | Lyophilized from a 0.2 µm filtered solution of PBS; pH 7.4. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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