IL21R Antibody (PACO13985)
- SKU:
- PACO13985
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | IL21R Antibody (PACO13985) |
| Antibody SKU: | PACO13985 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:25-1:100 |
| Species Reactivity: | Human |
| Immunogen: | Fusion protein of human IL21R |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO13985(IL21R Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO13985(IL21R Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described. |
| Synonyms: | interleukin 21 receptorp |
| UniProt Protein Function: | IL21R: This is a receptor for interleukin-21 |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, cytokine Chromosomal Location of Human Ortholog: 16p11 Cellular Component: integral to membrane Molecular Function:interleukin-21 receptor activity Biological Process: natural killer cell activation Disease: Ige Responsiveness, Atopic; Il21r Immunodeficiency |
| NCBI Summary: | The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2010] |
| UniProt Code: | Q9HBE5 |
| NCBI GenInfo Identifier: | 20454997 |
| NCBI Gene ID: | 50615 |
| NCBI Accession: | Q9HBE5.1 |
| UniProt Secondary Accession: | Q9HBE5,Q96HZ1, Q9HB91, A8K9E8, D3DWF7, |
| UniProt Related Accession: | Q9HBE5 |
| Molecular Weight: | 538 |
| NCBI Full Name: | Interleukin-21 receptor |
| NCBI Synonym Full Names: | interleukin 21 receptor |
| NCBI Official Symbol: | IL21R |
| NCBI Official Synonym Symbols: | NILR; CD360 |
| NCBI Protein Information: | interleukin-21 receptor; IL-21 receptor; novel interleukin receptor |
| UniProt Protein Name: | Interleukin-21 receptor |
| UniProt Synonym Protein Names: | Novel interleukin receptor; CD_antigen: CD360 |
| Protein Family: | Interleukin-21 receptor |
| UniProt Gene Name: | IL21R |
| UniProt Entry Name: | IL21R_HUMAN |
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