IL21 Antibody (PACO43168)
- SKU:
- PACO43168
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
| Antibody Name: | IL21 Antibody (PACO43168) |
| Antibody SKU: | PACO43168 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Interleukin-21 protein (25-162AA) |
| Form: | Liquid |
| Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Purification Method: | Antigen Affinity Purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human breast cancer using PACO43168 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human spleen tissue using PACO43168 at dilution of 1:100. |
| Background: | Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG1 and IgG3 in B-cells (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon γ production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation. |
| Synonyms: | Interleukin-21 (IL-21) (Za11), IL21 |
| UniProt Protein Function: | IL21: Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation. Belongs to the IL-15/IL-21 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cytokine; Apoptosis; Secreted, signal peptide; Secreted; Cell development/differentiation Chromosomal Location of Human Ortholog: 4q26-q27 Molecular Function:hematopoietin/interferon-class (D200-domain) cytokine receptor binding; interleukin-2 receptor binding Biological Process: cell maturation; positive regulation of B cell proliferation; positive regulation of cell proliferation; positive regulation of cytokine production; positive regulation of inflammatory response; positive regulation of interleukin-17 production; positive regulation of natural killer cell mediated cytotoxicity; positive regulation of T cell proliferation; positive regulation of tissue remodeling; positive regulation of tyrosine phosphorylation of Stat1 protein; positive regulation of tyrosine phosphorylation of Stat3 protein; tyrosine phosphorylation of Stat3 protein Disease: Immunodeficiency, Common Variable, 11 |
| NCBI Summary: | This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011] |
| UniProt Code: | Q9HBE4 |
| NCBI GenInfo Identifier: | 55976599 |
| NCBI Gene ID: | 59067 |
| NCBI Accession: | Q9HBE4.2 |
| UniProt Secondary Accession: | Q9HBE4,A5J0L4, |
| UniProt Related Accession: | Q9HBE4 |
| Molecular Weight: | 16,867 Da |
| NCBI Full Name: | Interleukin-21 |
| NCBI Synonym Full Names: | interleukin 21 |
| NCBI Official Symbol: | IL21 |
| NCBI Official Synonym Symbols: | Za11; IL-21; CVID11 |
| NCBI Protein Information: | interleukin-21 |
| UniProt Protein Name: | Interleukin-21 |
| UniProt Synonym Protein Names: | Za11 |
| Protein Family: | Interleukin |
| UniProt Gene Name: | IL21 |
| UniProt Entry Name: | IL21_HUMAN |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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