Human ZFAND5 Recombinant Protein (RPPB5180)

(No reviews yet) Write a Review

제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.

주문
SKU:
RPPB5180
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
ZFAND5
Synonyms:
Zinc Finger
Synonyms:
AN1-Type Domain 5
Synonyms:
Zinc Finger Protein 216
Synonyms:
ZNF216
Source:
Escherichia Coli
Uniprot:
O76080
€0.00
Frequently bought together:

Description

Product Name:Human ZFAND5 Recombinant Protein
Product Code:RPPB5180
Size:20µg
Species:Human
Target:ZFAND5
Synonyms:Zinc Finger, AN1-Type Domain 5, Zinc Finger Protein 216, ZNF216,Zinc Finger A20 Domain-Containing Protein 2, Zinc Finger, A20 Domain Containing2, ZA20D2, AN1-Type Zinc Finger Protein 5, ZFAND5A, AN1-type zinc fingerprotein 5, Zinc finger A20 domain-containing protein 2, Zinc finger protein 216.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:ZFAND5 protein solution (0.5mg/ml) containing 20mM Phosphatebuffer saline (pH 8.0), 30% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMAQETNQ TPGPMLCSTG CGFYGNPRTN GMCSVCYKEH LQRQQNSGRMSPMGTASGSN SPTSDSASVQ RADTSLNNCE GAAGSTSEKS RNVPVAALPV TQQMTEMSIS REDKITTPKTEVSEPVVTQP SPSVSQPSTS QSEEKAPELP KPKKNRCFMC RKKVGLTGFD CRCGNLFCGL HRYSDKHNCPYDYKAEAAAK IRKENPVVVA EKIQRI

Zinc Finger, AN1-Type Domain 5, also known as ZFAND5 is implicated inprotein degradation through the ubiquitin-proteasome system. ZFAND5 performs byanchoring ubiquitinated proteins to the proteasome and takes part inubiquitin-mediated protein degradation during muscle atrophy. Furthemore,ZFAND5 plays a role in the regulation of NF-kappa-B activation as well asapoptosis. ZFAND5 inhibits NF-kappa-B activation as well as tumor necrosisfactor (TNF), IL-1 and TLR4-induced NF-kappa-B activation.

ZFAND5 Human Recombinant produced in E.Coli is a single, non-glycosylatedpolypeptide chain containing 236 amino acids (1-213 a.a) and having a molecularmass of 25.5kDa (Molecular size on SDS-PAGE will appear higher).ZFAND5 is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.

UniProt Protein Function:Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation.
UniProt Code:O76080
NCBI GenInfo Identifier:156231047
NCBI Gene ID:7763
NCBI Accession:NP_001095890.1
UniProt Secondary Accession:O76080,A8K484,
UniProt Related Accession:O76080
Molecular Weight:23,132 Da
NCBI Full Name:AN1-type zinc finger protein 5
NCBI Synonym Full Names:zinc finger AN1-type containing 5
NCBI Official Symbol:ZFAND5  
NCBI Official Synonym Symbols:ZA20D2; ZNF216; ZFAND5A  
NCBI Protein Information:AN1-type zinc finger protein 5
UniProt Protein Name:AN1-type zinc finger protein 5
UniProt Synonym Protein Names:Zinc finger A20 domain-containing protein 2; Zinc finger protein 216
Protein Family:AN1-type zinc finger protein
UniProt Gene Name:ZFAND5  
View AllClose

Related Products