Human YWHAH Recombinant Protein (RPPB2686)
- SKU:
- RPPB2686
- Product type:
- Recombinant Protein
- Size:
- 25ug
- Species:
- Human
- Target:
- YWHAH
- Synonyms:
- 14-3-3 ETA
- YWHAH
- YWHA1
- Protein AS1
- Source:
- Escherichia Coli
- Uniprot:
- Q04917
Description
Product Name: | Human YWHAH Recombinant Protein |
Product Code: | RPPB2686 |
Size: | 25µg |
Species: | Human |
Target: | YWHAH |
Synonyms: | 14-3-3 ETA, YWHAH, YWHA1, Protein AS1, Tyr-3/Trp-5 Monooxygenase Activation Protein ETA. |
Source: | Escherichia Coli |
Physical Appearance: | Sterile filtered colorless solution. |
Formulation: | YWHAH solution containing 20mM Tris pH-8. |
Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
Purity: | Greater than 95.0% as determined by SDS-PAGE. |
Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGDREQLLQR ARLAEQAERY DDMASAMKAV TELNEPLSNE DRNLLSVAYK NVVGARRSSW RVISSIEQKT MADGNEKKLE KVKAYREKIE KELETVCNDV LSLLDKFLIK NCNDFQYESK VFYLKMKGDY YRYLAEVASG EKKNSVVEAS EAAYKEAFEI SKEQMQPTHP IRLGLALNFS VFYYEIQNAP EQACLLAKQA FDDAIAELDT LNEDSYKDST LIMQLLRDNL TLWTSDQQDE EAGEGN |
YWHAH belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. 14-3-3 ETA is found in plants and mammals, and there is 99% identity to the mouse, rat and bovine orthologs. YWHAH gene contains a 7 base pair repeat sequence in its 5' UTR, and changes in the number of this repeat has been associated with early-onset schizophrenia.14-3-3 eta is specific to the site of joint inflammation. 14-3-3 proteins are colocalized with Lewy bodies in Parkinson disease, though there is no specific staining for the 14-3-3 eta subunit. There are 3 different isoforms types of 14-3-3: Beta, Gamma and ETA that are DAL-1/Protein 4.1B-binding proteins.
YWHAH Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 266 amino acids and having a molecular mass of 30.3 kDa. YWHAH is fused to an N-Terminal His Tag and purified by proprietary chromatographic techniques.
UniProt Protein Function: | 14-3-3 eta: a protein of the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. A multifunctional regulator of the cell signaling processes. |
UniProt Protein Details: | Protein type:Nuclear receptor co-regulator; Adaptor/scaffold Chromosomal Location of Human Ortholog: 22q12.3 Cellular Component: cytoplasmic vesicle membrane; cytoplasm; plasma membrane; cytosol Molecular Function:insulin-like growth factor receptor binding; protein domain specific binding; protein binding; enzyme binding; sodium channel regulator activity; protein heterodimerization activity; actin binding; glucocorticoid receptor binding Biological Process: intracellular protein transport; substantia nigra development; regulation of neuron differentiation; apoptosis; glucocorticoid receptor signaling pathway; positive regulation of transcription, DNA-dependent; regulation of synaptic plasticity; glucocorticoid catabolic process; negative regulation of dendrite morphogenesis; regulation of sodium ion transport |
NCBI Summary: | This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and bovine orthologs. This gene contains a 7 bp repeat sequence in its 5' UTR, and changes in the number of this repeat have been associated with early-onset schizophrenia and psychotic bipolar disorder. [provided by RefSeq, Jun 2009] |
UniProt Code: | Q04917 |
NCBI GenInfo Identifier: | 4507951 |
NCBI Gene ID: | 7533 |
NCBI Accession: | NP_003396.1 |
UniProt Related Accession: | Q04917 |
Molecular Weight: | 28,219 Da |
NCBI Full Name: | 14-3-3 protein eta |
NCBI Synonym Full Names: | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta |
NCBI Official Symbol: | YWHAH |
NCBI Official Synonym Symbols: | YWHA1 |
NCBI Protein Information: | 14-3-3 protein eta; 14-3-3 eta; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide |
UniProt Protein Name: | 14-3-3 protein eta |
UniProt Synonym Protein Names: | Protein AS1 |
Protein Family: | 14-3-3 protein |
UniProt Gene Name: | YWHAH |
UniProt Entry Name: | 1433F_HUMAN |