Human WIBG Recombinant Protein (RPPB5149)
- SKU:
- RPPB5149
- Product type:
- Recombinant Protein
- Size:
- 10ug
- Species:
- Human
- Target:
- WIBG
- Synonyms:
- PYM
- Partner of Y14 and mago
- MGC13064
- WIBG
- Source:
- Escherichia Coli
- Uniprot:
- Q9BRP8
Description
| Product Name: | Human WIBG Recombinant Protein |
| Product Code: | RPPB5149 |
| Size: | 10µg |
| Species: | Human |
| Target: | WIBG |
| Synonyms: | PYM, Partner of Y14 and mago, MGC13064, WIBG, BCGN Homolog, Protein wibg homolog. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | WIBG Human solution containing 20mM Tris pH-8, 0.1M NaCl & 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MEAAGSPAAT ETGKYIASTQ RPDGTWRKQR RVKEGYVPQE EVPVYENKYV KFFKSKPELP PGLSPEATAP VTPSRPEGGE PGLSKTAKRN LKRKEKRRQQ QEKGEAEALS RTLDKVSLEE TAQLPSAPQG SRAAPTAASD QPDSAATTEK AKKIKNLKKK LRQVEELQQR IQAGEVSQPS KEQLEKLARR RALEEELEDL ELGLLEHHHH HH |
WIBG is a cooperateing partner of Mago-Y14. The Mago-Y14 heterodimer is a key protein of the EJC(exon junction complex) that is deposited on mRNAs as a consequence of splicing and influences postsplicing mRNA metabolism. WIBG is a cytoplasmic RNA-binding protein that is excluded from the nucleus by Crm1. WIBG relates directly with Mago-Y14 by means of its N-terminal domain.
WIBG Recombinant Human produced in E.Coli is a single, non-glycosylated polypeptide chain containing 212 amino acids (1-204 a.a.) and having a molecular mass of 23.7 kDa. The WIBG is fused to 8 amino acid His-Tag at C-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | WIBG: a conserved protein of unknown function. A potential RNA-binding protein. |
| UniProt Protein Details: | Protein type:RNA-binding; Nucleolus; Translation Chromosomal Location of Human Ortholog: 12q13.2 Molecular Function:protein binding; ribosome binding Biological Process: mRNA catabolic process, nonsense-mediated decay; positive regulation of translation |
| UniProt Code: | Q9BRP8 |
| NCBI GenInfo Identifier: | 74732911 |
| NCBI Gene ID: | 84305 |
| NCBI Accession: | Q9BRP8.1 |
| UniProt Secondary Accession: | Q9BRP8,Q8IXJ8, Q8N8E7, B6ZDM5, |
| UniProt Related Accession: | Q9BRP8 |
| Molecular Weight: | 22,705 Da |
| NCBI Full Name: | Partner of Y14 and mago |
| NCBI Synonym Full Names: | PYM homolog 1, exon junction complex associated factor |
| NCBI Official Symbol: | PYM1 |
| NCBI Official Synonym Symbols: | PYM; WIBG |
| NCBI Protein Information: | partner of Y14 and mago |
| UniProt Protein Name: | Partner of Y14 and mago |
| UniProt Synonym Protein Names: | PYM homolog 1 exon junction complex-associated factor |
| UniProt Gene Name: | PYM1 |
| UniProt Entry Name: | PYM1_HUMAN |
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