Human WFDC2 Recombinant Protein (RPPB5059)
- SKU:
- RPPB5059
- Product type:
- Recombinant Protein
- Size:
- 10ug
- Species:
- Human
- Target:
- WFDC2
- Synonyms:
- WAP four-disulfide core domain protein 2
- Epididymal secretory protein E4
- Major epididymis-specific protein E4
- Putative protease inhibitor WAP5
- Source:
- Escherichia Coli
- Uniprot:
- Q14508
Description
| Product Name: | Human WFDC2 Recombinant Protein |
| Product Code: | RPPB5059 |
| Size: | 10µg |
| Species: | Human |
| Target: | WFDC2 |
| Synonyms: | WAP four-disulfide core domain protein 2, Epididymal secretory protein E4, Major epididymis-specific protein E4, Putative protease inhibitor WAP5, WFDC2, HE4, WAP5, EDDM4, dJ461P17.6. |
| Source: | Escherichia Coli |
| Physical Appearance: | Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | WFDC2 filtered (0.4µm) and lyophilized from 0.5mg/ml in PBS buffer, pH 7.5. |
| Solubility: | It is recommended to add 200µl deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. WFDC2 is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture. |
| Stability: | Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MKHHHHHHASEKTGVCPELQ ADQNCTQECV SDSECADNLK CCSAGCATFC SLPNDKEGSC PQVNINFPQL GLCRDQCQVD SQCPGQMKCC RNGCGKVSCV TPNF |
WAP four-disulfide core domain protein 2 (WFDC2) is a protease inhibitor, which belongs to the WFDC domain family. WFDC2 is effective with a broad range of proteases, e.g. aspartic, serine or thiol proteases. WFDC2 is expressed in several normal tissues, including the male reproductive system, regions of the respiratory tract and nasopharynx. WFDC2 may be involved in sperm maturation. WFDC2 is also highly expressed in a number of tumors cells lines, such ovarian, colon, breast, lung and renal cells lines.
WFDC2 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain (31-124) containing 104 amino acids including a 10 a.a N-terminal His tag. The total molecular mass is 11.3kDa (calculated).
| UniProt Protein Function: | WFDC2: a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation. [provided by RefSeq, Jul 2008] |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 20q13.12 Cellular Component: extracellular space Molecular Function:serine-type endopeptidase inhibitor activity; aspartic-type endopeptidase inhibitor activity; endopeptidase inhibitor activity; cysteine protease inhibitor activity Biological Process: spermatogenesis; proteolysis |
| NCBI Summary: | This gene encodes a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q14508 |
| NCBI GenInfo Identifier: | 20141958 |
| NCBI Gene ID: | 10406 |
| NCBI Accession: | Q14508.2 |
| UniProt Secondary Accession: | Q14508,Q6IB27, Q8WXV9, Q8WXW0, Q8WXW1, Q8WXW2, Q96KJ1 A2A2A5, A2A2A6, A6PVD5, |
| UniProt Related Accession: | Q14508 |
| Molecular Weight: | 124 |
| NCBI Full Name: | WAP four-disulfide core domain protein 2 |
| NCBI Synonym Full Names: | WAP four-disulfide core domain 2 |
| NCBI Official Symbol: | WFDC2 |
| NCBI Official Synonym Symbols: | HE4; WAP5; EDDM4; dJ461P17.6 |
| NCBI Protein Information: | WAP four-disulfide core domain protein 2; epididymal protein 4; epididymal secretory protein E4; putative protease inhibitor WAP5; WAP domain containing protein HE4-V4; major epididymis-specific protein E4; epididymis-specific, whey-acidic protein type, four-disulfide core |
| UniProt Protein Name: | WAP four-disulfide core domain protein 2 |
| UniProt Synonym Protein Names: | Epididymal secretory protein E4; Major epididymis-specific protein E4; Putative protease inhibitor WAP5 |
| Protein Family: | WAP four-disulfide core domain protein |
| UniProt Gene Name: | WFDC2 |
| UniProt Entry Name: | WFDC2_HUMAN |
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