Human WFDC2 Recombinant Protein (RPPB5058)
- SKU:
- RPPB5058
- Product type:
- Recombinant Protein
- Size:
- 10ug
- Species:
- Human
- Target:
- WFDC2
- Synonyms:
- WAP four-disulfide core domain protein 2
- Epididymal secretory protein E4
- Major epididymis-specific protein E4
- Putative protease inhibitor WAP5
- Source:
- Escherichia Coli
- Uniprot:
- Q14508
Description
| Product Name: | Human WFDC2 Recombinant Protein |
| Product Code: | RPPB5058 |
| Size: | 10µg |
| Species: | Human |
| Target: | WFDC2 |
| Synonyms: | WAP four-disulfide core domain protein 2, Epididymal secretory protein E4, Major epididymis-specific protein E4, Putative protease inhibitor WAP5, WFDC2, HE4, WAP5, EDDM4, dJ461P17.6. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | The protein was filtered (0.2µm) and lyophilized from a concentrated solution containing PBS, pH 7.0. |
| Solubility: | It is recommended to reconstitute the lyophilized Human WAP Four-Disulfide Core Domain 2 in sterile 18M?-cm H2O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized WAP Four-Disulfide Core Domain 2 Human Recombinant although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution WFDC2 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | EKTGVCPELQ ADQNCTQECV SDSECADNLK CCSAGCATFC SLPNDKEGSC PQVNINFPQL GLCRDQCQVD SQCPGQMKCC RNGCGKVSCV TPNF |
WAP four-disulfide core domain protein 2 (WFDC2) is a protease inhibitor, which belongs to the WFDC domain family. WFDC2 is effective with a broad range of proteases, e.g. aspartic, serine or thiol proteases. WFDC2 is expressed in several normal tissues, including the male reproductive system, regions of the respiratory tract and nasopharynx. WFDC2 may be involved in sperm maturation. WFDC2 is also highly expressed in a number of tumors cells lines, such ovarian, colon, breast, lung and renal cells lines.
WAP Four-Disulfide Core Domain 2 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 94 amino acids and having a molecular mass of 10.0 kDa (although migrates with an apparent molecular mass of 16.9 kDa in SDS-PAGE). The WFDC2 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | WFDC2: a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation. [provided by RefSeq, Jul 2008] |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 20q13.12 Cellular Component: extracellular space Molecular Function:serine-type endopeptidase inhibitor activity; aspartic-type endopeptidase inhibitor activity; endopeptidase inhibitor activity; cysteine protease inhibitor activity Biological Process: spermatogenesis; proteolysis |
| NCBI Summary: | This gene encodes a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q14508 |
| NCBI GenInfo Identifier: | 20141958 |
| NCBI Gene ID: | 10406 |
| NCBI Accession: | Q14508.2 |
| UniProt Secondary Accession: | Q14508,Q6IB27, Q8WXV9, Q8WXW0, Q8WXW1, Q8WXW2, Q96KJ1 A2A2A5, A2A2A6, A6PVD5, |
| UniProt Related Accession: | Q14508 |
| Molecular Weight: | 124 |
| NCBI Full Name: | WAP four-disulfide core domain protein 2 |
| NCBI Synonym Full Names: | WAP four-disulfide core domain 2 |
| NCBI Official Symbol: | WFDC2 |
| NCBI Official Synonym Symbols: | HE4; WAP5; EDDM4; dJ461P17.6 |
| NCBI Protein Information: | WAP four-disulfide core domain protein 2; epididymal protein 4; epididymal secretory protein E4; putative protease inhibitor WAP5; WAP domain containing protein HE4-V4; major epididymis-specific protein E4; epididymis-specific, whey-acidic protein type, four-disulfide core |
| UniProt Protein Name: | WAP four-disulfide core domain protein 2 |
| UniProt Synonym Protein Names: | Epididymal secretory protein E4; Major epididymis-specific protein E4; Putative protease inhibitor WAP5 |
| Protein Family: | WAP four-disulfide core domain protein |
| UniProt Gene Name: | WFDC2 |
| UniProt Entry Name: | WFDC2_HUMAN |
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