Human VSNL1 Recombinant Protein (RPPB5137)
- SKU:
- RPPB5137
- Product type:
- Recombinant Protein
- Size:
- 10ug
- Species:
- Human
- Target:
- VSNL1
- Synonyms:
- VISL1
- VISL-1
- VIS1
- VIS-1
- Source:
- Escherichia Coli
- Uniprot:
- P62760
Description
| Product Name: | Human VSNL1 Recombinant Protein |
| Product Code: | RPPB5137 |
| Size: | 10µg |
| Species: | Human |
| Target: | VSNL1 |
| Synonyms: | VISL1, VISL-1, VIS1, VIS-1, VILIP, HLP3, Hippocalcin-like protein 3, VSNL1, VILIP-1, VILIP1, HLP-3, HPCAL3, HUVISL1, Visinin-like protein 1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | The sterile filtered concentrated (0.5mg/ml) protein solution was lyophilized with 20mM Tris & 20mM NaCl pH-7.5. |
| Solubility: | Add sterile deionized water to a working concentration of 0.5mg/ml and let the lyophilized pellet dissolve completely. |
| Stability: | Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/ thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MKHHHHHHAS MGKQNSKLAP EVMEDLVKST EFNEHELKQW YKGFLKDCPS GRLNLEEFQQ LYVKFFPYGD ASKFAQHAFR TFDKNGDGTI DFREFICALS ITSRGSFEQK LNWAFNMYDL DGDGKITRVE MLEIIEAIYK MVGTVIMMKM NEDGLTPEQR VDKIFSKMDK NKDDQITLDE FKEAAKSDPS IVLLLQCDIQK |
VSNL1 is a member of the visinin/recoverin subfamily of neuronal calcium sensor proteins. VILIP1 is strongly expressed in granule cells of the cerebellum where it associates with membranes in a calcium-dependent manner and modulates intracellular signaling pathways of the central nervous system by directly or indirectly regulating the activity of adenylyl cyclase. Changes in cellular expression of VSNL1 were found in hipppocampi of schizophrenics, since more interneurons showed immunoreactivity. VILIP1 is expressed in pancreatic beta-cells. VILIP1 elevation enhances insulin secretion in cAMP-associated manner. Down-regulation of VILIP-1 decreased cAMP accumulation but increased insulin gene transcription. VILIP-1 interacts with cell membrane and actin-based cytoskeleton. VSNL1 modulates cAMP-accumulation in C6 glioma cells. HLP3 modulates cGMP-accumulation in transfected neural cells and cerebellar granule neurons.
Visinin-Like Protein-1 Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 201 amino acids and having a molecular mass of 23.4 kDa. Visinin-Like Protein-1 is fused to His tag at N-Terminus.The protein‘s amino acid sequence corrssponds toUniProtKB/Swiss-Prot entry P62760.Visinin-Like Protein-1 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | VSNL1: Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner. Belongs to the recoverin family. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 2p24.3 Molecular Function:calcium ion binding Biological Process: calcium-mediated signaling |
| NCBI Summary: | This gene is a member of the visinin/recoverin subfamily of neuronal calcium sensor proteins. The encoded protein is strongly expressed in granule cells of the cerebellum where it associates with membranes in a calcium-dependent manner and modulates intracellular signaling pathways of the central nervous system by directly or indirectly regulating the activity of adenylyl cyclase. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P62760 |
| NCBI GenInfo Identifier: | 51338696 |
| NCBI Gene ID: | 7447 |
| NCBI Accession: | P62760.2 |
| UniProt Secondary Accession: | P62760,P28677, P29103, P42323, Q9UM20, D6W515, |
| UniProt Related Accession: | P62760 |
| Molecular Weight: | 191 |
| NCBI Full Name: | Visinin-like protein 1 |
| NCBI Synonym Full Names: | visinin-like 1 |
| NCBI Official Symbol: | VSNL1 |
| NCBI Official Synonym Symbols: | HLP3; VILIP; HPCAL3; HUVISL1; VILIP-1 |
| NCBI Protein Information: | visinin-like protein 1; VLP-1; hippocalcin-like protein 3 |
| UniProt Protein Name: | Visinin-like protein 1 |
| UniProt Synonym Protein Names: | Hippocalcin-like protein 3; HLP3 |
| Protein Family: | Visinin-like protein |
| UniProt Gene Name: | VSNL1 |
| UniProt Entry Name: | VISL1_HUMAN |
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