Human VPS28 Recombinant Protein (RPPB5132)
- SKU:
- RPPB5132
- Product type:
- Recombinant Protein
- Size:
- 50ug
- Species:
- Human
- Target:
- VPS28
- Synonyms:
- Vacuolar protein sorting-associated protein 28 homolog
- ESCRT-I complex subunit VPS28
- H-Vps28
- VPS28
- Source:
- Escherichia Coli
- Uniprot:
- Q9UK41
Description
| Product Name: | Human VPS28 Recombinant Protein |
| Product Code: | RPPB5132 |
| Size: | 50µg |
| Species: | Human |
| Target: | VPS28 |
| Synonyms: | Vacuolar protein sorting-associated protein 28 homolog, ESCRT-I complex subunit VPS28, H-Vps28, VPS28, MGC60323. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The VPS28 protein solution contains 20mM Tris-HCl buffer (pH 7.5), 1mM DTT and 10% Glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MFHGIPATPG IGAPGNKPEL YEEVKLYKNA REREKYDNMA ELFAVVKTMQ ALEKAYIKDC VSPSEYTAAC SRLLVQYKAA FRQVQGSEIS SIDEFCRKFR LDCPLAMERI KEDRPITIKD DKGNLNRCIA DVVSLFITVM DKLRLEIRAM DEIQPDLREL METMHRMSHL PPDFEGRQTV SQWLQTLSGM SASDELDDSQ VRQMLFDLES AYNAFNRFLH A |
VPS28 is a subunit of the ESCRT-I complex (endosomal complexes required for transport) involved in the sorting of ubiquitinated proteins. VPS28 is involved in endosomal sorting of cell surface receptors using a multivesicular body/late endosome pathway. VSP28 binding with the TSG101 may have significant roles in budding of Retroviruses, such as HIV-1 and Ebola virus.VSP28 interacts with TSG101, VPS37B, VPS37C, FAM125A and FAM125B, and also with VPS36, this interaction mediates the association with the ESCRT-II complex. Furthermore it interacts with SNF8 and VPS25 and CEP55.
VPS28 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 221 amino acids (1-221 a.a.) and having a molecular mass of 25.4kDa.The VPS28 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Component of the ESCRT-I complex, a regulator of vesicular trafficking process. |
| NCBI Summary: | This gene encodes a protein subunit of the ESCRT-I complex (endosomal complexes required for transport), which functions in the transport and sorting of proteins into subcellular vesicles. This complex can also be hijacked to facilitate the budding of enveloped viruses from the cell membrane. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013] |
| UniProt Code: | Q9UK41 |
| NCBI GenInfo Identifier: | 7705885 |
| NCBI Gene ID: | 51160 |
| NCBI Accession: | NP_057292 |
| UniProt Secondary Accession: | Q9UK41,Q86VK0, |
| UniProt Related Accession: | Q9UK41 |
| Molecular Weight: | 25.4 kDa (221aa), confirmed by MALDI-TOF. |
| NCBI Full Name: | vacuolar protein sorting-associated protein 28 homolog isoform 1 |
| NCBI Synonym Full Names: | VPS28, ESCRT-I subunit |
| NCBI Official Symbol: | VPS28 |
| NCBI Protein Information: | vacuolar protein sorting-associated protein 28 homolog |
| UniProt Protein Name: | Vacuolar protein sorting-associated protein 28 homolog |
| UniProt Synonym Protein Names: | ESCRT-I complex subunit VPS28 |
| Protein Family: | Vacuolar protein sorting-associated protein |
| UniProt Gene Name: | VPS28 |
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