Human Urokinase/uPA Recombinant Protein (RPES3492)

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SKU:
RPES3492
Product type:
Recombinant Protein
Host species:
Human Cells
Reactivity:
Human
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Description

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Human Urokinase/uPA Recombinant Protein

Recombinant Human Urokinase-Type Plasminogen Activator is a serine protease, which specifically cleaves the zymogen plasminogen to form the active enzyme plasmin. Urokinase-Type Plasminogen Activator is a potent marker of invasion and metastasis in many human cancers associated with breast, colon, stomach, bladder, brain, ovary and endometrium. Human Urokinase-Type Plasminogen Activator is initially synthesized as 431 amino acid precursor with a N-terminal signal peptide residues. The single chain molecule is processed into a disulfide-linked two-chain molecule. There exists two forms A chain, the long A chain contains an EGF-like domain that is responsible for binding of the uPA receptor. The B chain corresponds to the catalytic domain.

Product Name:Human Urokinase/uPA Recombinant Protein (RPES3492)
Product Code:RPES3492
Size:10µg
Species:Human
Expressed Host:Human Cells
Synonyms:Urokinase-Type Plasminogen Activator, U-Plasminogen Activator, uPA,PLAU,ATF,BDPLT5,QPD,u-PA,UPA,URK
Accession:NP_002649.1
Sequence:Ser21-Leu431
Fusion tag:C-6His
Endotoxin:<1.0 EU per µg as determined by the LAL method.
Protein Construction:Recombinant Human Urokinase-Type Plasminogen Activator is produced by our Mammalian expression system and the target gene encoding Ser21-Leu431 is expressed with a 6His tag at the C-terminus.
Purity:> 95 % as determined by reducing SDS-PAGE.
Mol Mass:47.4 kDa
AP Mol Mass:52 kDa
Formulation:Supplied as a 0.2 µm filtered solution of 20mM HEPES, 150mM NaCl, 2mM CaCl, 10% Glycerol, pH 7.5.
Shipping:This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt, store it immediately at<-20°C.
Stability and Storage:Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

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