Human TSC22D3 Recombinant Protein (RPPB5026)

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SKU:
RPPB5026
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
TSC22D3
Synonyms:
TSC22 domain family protein 3
Synonyms:
DSIP-immunoreactive peptide
Synonyms:
Protein DIP
Synonyms:
hDIP
Source:
Escherichia Coli
Uniprot:
Q99576
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Description

Product Name:Human TSC22D3 Recombinant Protein
Product Code:RPPB5026
Size:10µg
Species:Human
Target:TSC22D3
Synonyms:TSC22 domain family protein 3, DSIP-immunoreactive peptide, Protein DIP, hDIP, Delta sleep-inducing peptide immunoreactor, Glucocorticoid-induced leucine zipper protein, GILZ, TSC-22-like protein, TSC-22-related protein, TSC-22R, TSC22D3, DSIPI, DIP.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:TSC22D3 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMNTEMYQ TPMEVAVYQL HNFSISFFSS LLGGDVVSVK LDNSASGASV VAIDNKIEQA MDLVKNHLMY AVREEVEILK EQIRELVEKN SQLERENTLL KTLASPEQLE KFQSCLSPEE PAPESPQVPE APGGSAV

TSC22 domain family protein 3 (TSC22D3) protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity which initiates the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, TSC22D3 has a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, TSC22D3 hinders anti-CD3-induced NFKB1 nuclear translocation. In vitro, TSC22D3 curbs AP1 and NFKB1 DNA-binding activities.

TSC22D3 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 157 amino acids (1-134 a.a) and having a molecular mass of 17.2kDa.TSC22D3 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:GILZ: Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities. Belongs to the TSC-22/Dip/Bun family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:DNA-binding

Chromosomal Location of Human Ortholog: Xq22.3

Cellular Component: cytosol

Biological Process: regulation of transcription, DNA-dependent

NCBI Summary:This gene encodes the anti-inflammatory protein glucocorticoid (GC)-induced leucine zipper. Expression of this gene stimulated by glucocorticoids and interleukin 10 and it appears to play a key role in the anti-inflammatory and immunosuppressive effects of this steroid. This protein has also been shown to inhibit pro-inflammatory molecules including nuclear factor κB. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
UniProt Code:Q99576
NCBI GenInfo Identifier:14195584
NCBI Gene ID:1831
NCBI Accession:Q99576.2
UniProt Secondary Accession:Q99576,Q5H9S3, Q5JRI9, Q6FIH6, Q8NAI1, Q8WVB9, Q9UBN5 Q9UG13,
UniProt Related Accession:Q99576
Molecular Weight:13,286 Da
NCBI Full Name:TSC22 domain family protein 3
NCBI Synonym Full Names:TSC22 domain family member 3
NCBI Official Symbol:TSC22D3  
NCBI Official Synonym Symbols:DIP; GILZ; DSIPI; TSC-22R  
NCBI Protein Information:TSC22 domain family protein 3
UniProt Protein Name:TSC22 domain family protein 3
UniProt Synonym Protein Names:DSIP-immunoreactive peptide; Protein DIP; hDIP; Delta sleep-inducing peptide immunoreactor; Glucocorticoid-induced leucine zipper protein; GILZ; TSC-22-like protein; TSC-22-related protein; TSC-22R
Protein Family:TSC22 domain family protein
UniProt Gene Name:TSC22D3  
UniProt Entry Name:T22D3_HUMAN
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