Human TRIB3 Recombinant Protein (RPPB2671)
- SKU:
- RPPB2671
- Product type:
- Recombinant Protein
- Size:
- 10ug
- Species:
- Human
- Target:
- TRIB3
- Synonyms:
- Cell Growth Regulator With EF-Hand Domain 1
- Cell GrowthRegulatory Gene 11 Protein
- Hydrophobestin
- CGR11
- Source:
- Escherichia Coli
- Uniprot:
- Q96RU7
Description
| Product Name: | Human TRIB3 Recombinant Protein |
| Product Code: | RPPB2671 |
| Size: | 10µg |
| Species: | Human |
| Target: | TRIB3 |
| Synonyms: | Cell Growth Regulator With EF-Hand Domain 1, Cell GrowthRegulatory Gene 11 Protein, Hydrophobestin, CGR11, Cell Growth Regulator WithEF Hand Domain Protein 1, Cell Growth Regulator With EF Hand Domain 1, Tribbleshomolog 3. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | TRIB3 protein solution (0.25mg/ml) containing 20mMTris-HCl buffer (pH8.0) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMRATPLA APAGSLSRKK RLELDDNLDT ERPVQKRARS GPQPRLPPCLLPLSPPTAPD RATAVATASR LGPYVLLEPE EGGRAYQALH CPTGTEYTCK VYPVQEALAV LEPYARLPPHKHVARPTEVL AGTQLLYAFF TRTHGDMHSL VRSRHRIPEP EAAVLFRQMA TALAHCHQHG LVLRDLKLCRFVFADRERKK LVLENLEDSC VLTGPDDSLW DKHACPAYVG PEILSSRASY SGKAADVWSL GVALFTMLAGHYPFQDSEPV LLFGKIRRGA YALPAGLSAP ARCLVRCLLR REPAERLTAT GILLHPWLRQ DPMPLAPTRSHLWEAAQVVP DGLGLDEARE EEGDREVVLY G |
Tribbles Pseudokinase 3, also known as TRIB3, is a putative proteinkinase which is induced by the transcription factor NF-kappaB. In addition,TRIB3 is a negative regulator of NF-kappaB, and can as well sensitize cells toTNF- and TRAIL-induced apoptosis. Furthermore, TRIB3 is able to negativelyregulate the cell survival serine-threonine kinase AKT1. One of the diseaseswhich are associated with TRIB3 is anoxia.
TRIB3 Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 381 amino acids (1-358 a.a) andhaving a molecular mass of 42.0kDa.TRIB3 is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.
| UniProt Protein Function: | TRB3: a Ca(2)/calmodulin-dependent protein kinase of the Trbl family. Induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. May negatively regulate the cell survival kinase AKT1. |
| UniProt Protein Details: | Protein type:Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Protein kinase, CAMK; CAMK group; Trbl family Chromosomal Location of Human Ortholog: 20p13-p12.2 Cellular Component: nucleoplasm; plasma membrane; cytosol; nucleus Molecular Function:protein binding; protein kinase inhibitor activity; ubiquitin protein ligase binding; ubiquitin-protein ligase regulator activity; kinase activity; transcription corepressor activity; protein kinase binding; ATP binding Biological Process: epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; transcription, DNA-dependent; nerve growth factor receptor signaling pathway; positive regulation of protein binding; cellular lipid metabolic process; negative regulation of transcription from RNA polymerase II promoter; negative regulation of fat cell differentiation; protein amino acid phosphorylation; cellular response to insulin stimulus; regulation of MAP kinase activity; positive regulation of ubiquitin-protein ligase activity; insulin receptor signaling pathway; negative regulation of protein kinase activity; innate immune response; negative regulation of transcription, DNA-dependent; negative regulation of fatty acid biosynthetic process |
| NCBI Summary: | The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1. Differential promoter usage and alternate splicing result in multiple transcript variants. [provided by RefSeq, Jul 2014] |
| UniProt Code: | Q96RU7 |
| NCBI GenInfo Identifier: | 28201830 |
| NCBI Gene ID: | 57761 |
| NCBI Accession: | Q96RU7.2 |
| UniProt Related Accession: | Q96RU7 |
| Molecular Weight: | 35kDa |
| NCBI Full Name: | Tribbles homolog 3 |
| NCBI Synonym Full Names: | tribbles pseudokinase 3 |
| NCBI Official Symbol: | TRIB3 |
| NCBI Official Synonym Symbols: | NIPK; SINK; TRB3; SKIP3; C20orf97 |
| NCBI Protein Information: | tribbles homolog 3 |
| UniProt Protein Name: | Tribbles homolog 3 |
| UniProt Synonym Protein Names: | Neuronal cell death-inducible putative kinase; SINK; p65-interacting inhibitor of NF-kappa-B |
| Protein Family: | Tribbles |
| UniProt Gene Name: | TRIB3 |
| UniProt Entry Name: | TRIB3_HUMAN |
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