Human TRIAP1 Recombinant Protein (RPPB5005)

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SKU:
RPPB5005
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
TRIAP1
Synonyms:
TP53 Regulated Inhibitor of Apoptosis 1
Synonyms:
P53-Inducible Cell-Survival Factor
Synonyms:
Mitochondrial Distribution And Morphology 35 Homolog
Synonyms:
Protein 15E11
Source:
Escherichia Coli
Uniprot:
O43715
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Description

Product Name:Human TRIAP1 Recombinant Protein
Product Code:RPPB5005
Size:20µg
Species:Human
Target:TRIAP1
Synonyms:TP53 Regulated Inhibitor of Apoptosis 1, P53-Inducible Cell-Survival Factor, Mitochondrial Distribution And Morphology 35 Homolog, Protein 15E1.1, MDM35, WF-1, p53CSV, HSPC132.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:TRIAP1 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 0.1M NaCl, 1mM DTT and 20% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles.
Purity:Greaterthan 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMNSVGEA CTDMKREYDQ CFNRWFAEKF LKGDSSGDPC TDLFKRYQQC VQKAIKEKEI PIEGLEFMGH GKEKPENSS

TRIAP1 has a p53-binding site in its second exon. TRIAP1 expression is reduced by small interfering RNA enhanced apoptosis, while overexpression of TRIAP1 protects cells from apoptosis triggered by DNA damage. TRIAP1 is highly induced when cells have low levels of genotoxic stresses, but not when DNA damage is severe. TRIAP1 is able to control apoptotic pathways by interacting with Hsp70 which inhibits activity of apoptosis protease activating factor-1.

TRIAP1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 99 amino acids (1-76 a.a) and having a molecular mass of 11.2kDa.TRIAP1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:TRIAP1: Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis. Belongs to the TRIAP1/MDM35 family.
UniProt Protein Details:

Protein type:Apoptosis; Mitochondrial; Inhibitor

Chromosomal Location of Human Ortholog: 12q24.31

Cellular Component: protein complex; mitochondrion; perinuclear region of cytoplasm; mitochondrial intermembrane space

Molecular Function:protein binding; p53 binding

Biological Process: DNA damage response, signal transduction by p53 class mediator; positive regulation of transcription from RNA polymerase II promoter; phospholipid transport; negative regulation of caspase activity; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; negative regulation of apoptosis

UniProt Code:O43715
NCBI GenInfo Identifier:9910620
NCBI Gene ID:51499
NCBI Accession:O43715.1
UniProt Secondary Accession:O43715,Q5RKS5, Q6LCA7, B2R4Z7,
UniProt Related Accession:O43715
Molecular Weight:76
NCBI Full Name:TP53-regulated inhibitor of apoptosis 1
NCBI Synonym Full Names:TP53 regulated inhibitor of apoptosis 1
NCBI Official Symbol:TRIAP1  
NCBI Official Synonym Symbols:WF-1; MDM35; P53CSV; HSPC132  
NCBI Protein Information:TP53-regulated inhibitor of apoptosis 1; protein 15E1.1; p53-inducible cell-survival factor; mitochondrial distribution and morphology 35 homolog
UniProt Protein Name:TP53-regulated inhibitor of apoptosis 1
UniProt Synonym Protein Names:Protein 15E1.1; WF-1; p53-inducible cell-survival factor; p53CSV
Protein Family:TP53-regulated inhibitor of apoptosis
UniProt Gene Name:TRIAP1  
UniProt Entry Name:TRIA1_HUMAN
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