Human TRAF1 Recombinant Protein (RPPB4998)

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SKU:
RPPB4998
Product type:
Recombinant Protein
Size:
25ug
Species:
Human
Target:
TRAF1
Synonyms:
TRAF-1
Synonyms:
EBI6
Synonyms:
Epstein-Barr virus-induced protein 6
Synonyms:
TNF Receptor-Associated Factor 1
Source:
Escherichia Coli
Uniprot:
Q13077
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Description

Product Name:Human TRAF1 Recombinant Protein
Product Code:RPPB4998
Size:25µg
Species:Human
Target:TRAF1
Synonyms:TRAF-1, EBI6, Epstein-Barr virus-induced protein 6, TNF Receptor-Associated Factor 1, MGC:10353.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:TRAF1 Human solution containing 20mM Tris-HCl pH-8, 0.1M NaCl, 1mM DTT & 20% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MDGTFLWKIT NVTRRCHESA CGRTVSLFSP AFYTAKYGYK LCLRLYLNGD GTGKRTHLSL FIVIMRGEYD ALLPWPFRNK VTFMLLDQNN REHAIDAFRP DLSSASFQRP QSETNVASGC PLFFPLSKLQ SPKHAYVKDD TMFLKCIVET ST

TRAF1 is an adapter protein and signal transducer that connects members of the TNFR family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. TRAF1 mediates activation of NF-kappa-B and JNK and participates in apoptosis. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2.

TRAF1 Human Recombinant produced in E.Coli is a single, non-glycosylated,polypeptide chain containing 172 amino acids (266-416 a.a.) and having a molecular mass of 19.5 kDa. TRAF1 protein is fused to a 21 amino acid His tag at N-terminus and is purified by standard chromatography.

UniProt Protein Function:TRAF1: Adapter molecule that regulates the activation of NF- kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein- ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2. Homotrimer. Heterotrimer with TRAF2. Interacts with TNFRSF1A/TNFR1, TNFRSF1B/TNFR2, TNFRSF4, TNFRSF5/CD40, TNFRSF8/CD30, TNFRSF9/CD137, TNFRSF11A/RANK, TNFRSF13C, TNFRSF18/AITR, TNFRSF17/BCMA, TNFRSF19/TROY, TNFRSF19L/RELT, XEDAR, EDAR, Epstein-Barr virus BNFL1/LMP-1, TANK/ITRAF, TRAIP and RIPK2. Interacts with BIRC2 and BIRC3 N-terminus; a single BIRC2 or BIRC3 molecule interacts with a heterotrimer formed by TRAF1 and TRAF2. Interacts with NFATC2IP, TRAFD1 and with HIVEP3. Interacts with MAP3K14. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Apoptosis; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 9q33-q34

Cellular Component: cytoplasm

Molecular Function:protein binding; zinc ion binding; thioesterase binding; ubiquitin protein ligase binding; tumor necrosis factor receptor binding

Biological Process: apoptosis; protein complex assembly; signal transduction; activation of NF-kappaB transcription factor

NCBI Summary:The protein encoded by this gene is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from various receptors of the TNFR superfamily. This protein and TRAF2 form a heterodimeric complex, which is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF2 also interacts with inhibitor-of-apoptosis proteins (IAPs), and thus mediates the anti-apoptotic signals from TNF receptors. The expression of this protein can be induced by Epstein-Barr virus (EBV). EBV infection membrane protein 1 (LMP1) is found to interact with this and other TRAF proteins; this interaction is thought to link LMP1-mediated B lymphocyte transformation to the signal transduction from TNFR family receptors. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
UniProt Code:Q13077
NCBI GenInfo Identifier:6707734
NCBI Gene ID:7185
NCBI Accession:Q13077.1
UniProt Secondary Accession:Q13077,Q658U1, Q8NF13, B4DJ77,
UniProt Related Accession:Q13077
Molecular Weight:33,296 Da
NCBI Full Name:TNF receptor-associated factor 1
NCBI Synonym Full Names:TNF receptor-associated factor 1
NCBI Official Symbol:TRAF1  
NCBI Official Synonym Symbols:EBI6; MGC:10353  
NCBI Protein Information:TNF receptor-associated factor 1; Epstein-Bar virus-induced protein 6
UniProt Protein Name:TNF receptor-associated factor 1
UniProt Synonym Protein Names:Epstein-Barr virus-induced protein 6
Protein Family:TNF receptor-associated factor
UniProt Gene Name:TRAF1  
UniProt Entry Name:TRAF1_HUMAN
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