Human TPST1 Recombinant Protein (RPPB2345)
- SKU:
- RPPB2345
- Product type:
- Recombinant Protein
- Size:
- 5ug
- Species:
- Human
- Target:
- TPST1
- Synonyms:
- Tyrosylprotein Sulfotransferase 1
- EC 28220
- TPST-1
- Transport And Golgi Organization 13 Homolog A (Drosophila)
- Source:
- Sf9 Insect cells
- Uniprot:
- O60507
Description
| Product Name: | Human TPST1 Recombinant Protein |
| Product Code: | RPPB2345 |
| Size: | 5µg |
| Species: | Human |
| Target: | TPST1 |
| Synonyms: | Tyrosylprotein Sulfotransferase 1, EC 2.8.2.20, TPST-1,Transport And Golgi Organization 13 Homolog A (Drosophila), Transport And GolgiOrganization 13 Homolog A, Tyrosylprotein Sulfotransferase-1, TANGO13A. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | TPST1protein solution (0.25mg/ml) contains Phosphate Buffered Saline (pH 7.4) and10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles. |
| Purity: | Greaterthan 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | ADPQHAMECH HRIEERSQPV KLESTRTTVR TGLDLKANKT FAYHKDMPLI FIGGVPRSGT TLMRAMLDAH PDIRCGEETR VIPRILALKQ MWSRSSKEKI RLDEAGVTDE VLDSAMQAFL LEIIVKHGEP APYLCNKDPF ALKSLTYLSR LFPNAKFLLM VRDGRASVHS MISRKVTIAG FDLNSYRDCL TKWNRAIETM YNQCMEVGYK KCMLVHYEQL VLHPERWMRT LLKFLQIPWN HSVLHHEEMI GKAGGVSLSK VERSTDQVIK PVNVGALSKW VGKIPPDVLQ DMAVIAPMLA KLGYDPYANP PNYGKPDPKI IENTRRVYKG EFQLPDFLKE KPQTEQVEHH HHHH |
Tyrosylprotein Sulfotransferase 1, also known as TPST1 is the enzyme which catalyzes the sulfation reaction of protein tyrosines, a post-translational modification of proteins. TPST1 belongs to the protein sulfotransferase family. In addition, TPST1 utilizes 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) as the sulfonate donor and also binds proteins with target tyrosine residues to eventually form the tyrosine O-sulfate ester group in addition to the desulfonated 3’-phosphoadenosine-5’-phosphate.
TPST1 produced in Sf9 Baculovirus cells is a single,glycosylated polypeptide chain containing 354 amino acids (26-370 a.a.) andhaving a molecular mass of 40.6kDa (Migrates at 40-57kDa on SDS-PAGE underreducing conditions). TPST1 is expressed with a 6 amino acid His tag atC-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | TPST1: Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides. Belongs to the protein sulfotransferase family. |
| UniProt Protein Details: | Protein type:EC 2.8.2.20; Membrane protein, integral; Transferase Chromosomal Location of Human Ortholog: 7q11.21 Cellular Component: Golgi apparatus; membrane Biological Process: inflammatory response |
| UniProt Code: | O60507 |
| NCBI GenInfo Identifier: | 4507665 |
| NCBI Gene ID: | 8460 |
| NCBI Accession: | NP_003587 |
| UniProt Secondary Accession: | O60507,Q6FGM7, A4D2M0, |
| UniProt Related Accession: | O60507 |
| Molecular Weight: | 42kDa (369aa) |
| NCBI Full Name: | protein-tyrosine sulfotransferase 1 |
| NCBI Synonym Full Names: | tyrosylprotein sulfotransferase 1 |
| NCBI Official Symbol: | TPST1 |
| NCBI Official Synonym Symbols: | TANGO13A |
| NCBI Protein Information: | protein-tyrosine sulfotransferase 1 |
| UniProt Protein Name: | Protein-tyrosine sulfotransferase 1 |
| UniProt Synonym Protein Names: | Tyrosylprotein sulfotransferase 1; TPST-1 |
| Protein Family: | Protein-tyrosine sulfotransferase |
| UniProt Gene Name: | TPST1 |
| UniProt Entry Name: | TPST1_HUMAN |
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