Human TPPP Recombinant Protein (RPPB4993)

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SKU:
RPPB4993
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
TPPP
Synonyms:
Tubulin polymerization-promoting protein
Synonyms:
TPPP
Synonyms:
25 kDa brain-specific protein
Synonyms:
TPPP/p25
Source:
Escherichia Coli
Uniprot:
O94811
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Description

Product Name:Human TPPP Recombinant Protein
Product Code:RPPB4993
Size:10µg
Species:Human
Target:TPPP
Synonyms:Tubulin polymerization-promoting protein, TPPP, 25 kDa brain-specific protein, TPPP/p25, p24, p25-alpha, TPPP1, p25, p25alpha.
Source:Escherichia Coli
Physical Appearance:Filtered White lyophilized (freeze-dried) powder.
Formulation:TPPP filtered (0.4 µm) and lyophilized from 0.5mg/ml in 0.05M phosphate buffer and 0.075M NaCl, pH 7.4.
Solubility:It is recommended to add 200µl deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. TPPP is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.
Stability:Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MKHHHHHHASMADKAKPAKA ANRTPPKSPG DPSKDRAAKR LSLESEGAGE GAAASPELSA LEEAFRRFAV HGDARATGRE MHGKNWSKLC KDCQVIDGRN VTVTDVDIVF SKIKGKSCRT ITFEQFQEAL EELAKKRFKD KSSEEAVREV HRLIEGKAPI ISGVTKAISS PTVSRLTDTT KFTGSHKERF DPSGKGKGKA GRVDLVDESG YVSGYKHAGT YDQKVQGGK

Tubulin Polymerization Promoting Protein (TPPP) probably plays a part in the polymerization of tubulin into microtubules, as well as in microtubule bundling and the stabilization of existing microtubules, thus maintaining the integrity of the microtubule network. TPPP may also have a role in mitotic spindle assembly and nuclear envelope breakdown. TPPP/p235 level in cerebrospinal fluid is considerably higher in multiple sclerosis patients.

TPPP Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 229 amino acids including a 10 a.a N-terminal His tag. The total molecular mass is 24.9kDa (calculated).

UniProt Protein Function:TPPP: May play a role in the polymerization of tubulin into microtubules, microtubule bundling and the stabilization of existing microtubules, thus maintaining the integrity of the microtubule network. May play a role in mitotic spindle assembly and nuclear envelope breakdown. Belongs to the TPPP family.
UniProt Protein Details:

Protein type:Cytoskeletal

Chromosomal Location of Human Ortholog: 5p15.3

Cellular Component: cytoplasm; microtubule; nucleus; perinuclear region of cytoplasm

Molecular Function:microtubule binding; protein binding; tubulin binding

Biological Process: microtubule bundle formation; microtubule polymerization; positive regulation of protein complex assembly; positive regulation of protein polymerization

UniProt Code:O94811
NCBI GenInfo Identifier:28380097
NCBI Gene ID:11076
NCBI Accession:O94811.1
UniProt Related Accession:O94811
Molecular Weight:23,694 Da
NCBI Full Name:Tubulin polymerization-promoting protein
NCBI Synonym Full Names:tubulin polymerization promoting protein
NCBI Official Symbol:TPPP  
NCBI Official Synonym Symbols:p24; p25; TPPP1; TPPP/p25; p25alpha  
NCBI Protein Information:tubulin polymerization-promoting protein
UniProt Protein Name:Tubulin polymerization-promoting protein
UniProt Synonym Protein Names:25 kDa brain-specific protein; TPPP/p25; p24; p25-alpha
Protein Family:TPPP family protein
UniProt Gene Name:TPPP  
UniProt Entry Name:TPPP_HUMAN
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