Human TPO Recombinant Protein (RPPB2340)
- SKU:
- RPPB2340
- Product type:
- Recombinant Protein
- Size:
- 20ug
- Species:
- Human
- Target:
- TPO
- Synonyms:
- Thyroid peroxidase
- EC 11118
- TPO
- MSA
- Source:
- Sf9 Insect cells
- Uniprot:
- P07202
Description
| Product Name: | Human TPO Recombinant Protein |
| Product Code: | RPPB2340 |
| Size: | 20µg |
| Species: | Human |
| Target: | TPO |
| Synonyms: | Thyroid peroxidase, EC 1.11.1.8, TPO, MSA, TPX. |
| Source: | Sf9 Insect cells |
| Formulation: | TPO is supplied in 16mM HEPES pH-7.6, 160mM NaCl, 0.08mM Kl and 20% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95% as determined by SDS-PAGE. |
Thyroid Peroxidase (TPO) represents one of the main autoantigenic targets in autoimmune thyroid disease of humans. Its identity with the formerly so-called `microsomal antigen` has been shown several years ago. As an integral membrane glycoprotein it is restricted to the apical plasma membrane of the follicular epithelial cells and comprises two identical subunits of approx. 100 kDa molecular weight. The hemoprotein TPO plays a key role in the thyroid hormone biosynthesis by catalysing both the iodination of tyrosyl residues and the coupling of iodotyrosyl residues in thyroglobulin (TG) to form precursors of the thyroid hormones T4 and T3.
Thyroid Peroxidase Human Recombinant produced in SF9 is a glycosylated, polypeptide chain containing 834 amino acids and having a molecular mass of 92,872 Dalton (excluding glycosylation), 101 kDa total mass.The TPO is expressed with a -6xHis tag and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T3 and T4. |
| NCBI Summary: | This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2011] |
| UniProt Code: | P07202 |
| NCBI GenInfo Identifier: | 160281455 |
| NCBI Gene ID: | 7173 |
| NCBI Accession: | P07202.4 |
| UniProt Secondary Accession: | P07202,P09934, P09935, Q8IUL0, Q8NF94, Q8NF95, Q8NF96 Q8NF97, Q8TCI9, |
| UniProt Related Accession: | P07202 |
| Molecular Weight: | 96,699 Da |
| NCBI Full Name: | Thyroid peroxidase |
| NCBI Synonym Full Names: | thyroid peroxidase |
| NCBI Official Symbol: | TPO |
| NCBI Official Synonym Symbols: | MSA; TPX; TDH2A |
| NCBI Protein Information: | thyroid peroxidase |
| UniProt Protein Name: | Thyroid peroxidase |
| Protein Family: | Thyroid peroxidase |
| UniProt Gene Name: | TPO |
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