Human TNFRSF10D Recombinant Protein (RPPB1029)

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SKU:
RPPB1029
Product type:
Recombinant Protein
Size:
5ug
Species:
Human
Target:
TNFRSF10D
Synonyms:
Tumor necrosis factor receptor superfamily member 10D
Synonyms:
CD264
Synonyms:
DCR2
Synonyms:
TRAIL-R4
Source:
Sf9 Insect cells
Uniprot:
Q9UBN6
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Description

Product Name:Human TNFRSF10D Recombinant Protein
Product Code:RPPB1029
Size:5µg
Species:Human
Target:TNFRSF10D
Synonyms:Tumor necrosis factor receptor superfamily member 10D, CD264, DCR2, TRAIL-R4, TRAILR4, TRUNDD, Decoy receptor 2, TNF-related apoptosis-inducing ligand receptor 4, TRAIL receptor 4, TRAIL receptor with a truncated death domain.          
Source:Sf9 Insect cells
Physical Appearance:Sterile Filtered colorless solution.
Formulation:TNFRSF10D protein solution (0.5mg/ml) contains phosphate buffered saline (pH7.4) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:ATIPRQDEVP QQTVAPQQQR RSLKEEECPA GSHRSEYTGA CNPCTEGVDY TIASNNLPSC LLCTVCKSGQ TNKSSCTTTR DTVCQCEKGS FQDKNSPEMC RTCRTGCPRG MVKVSNCTPR SDIKCKNESA ASSTGKTPAA EETVTTILGM LASPYHVEPK SCDKTHTCPP CPAPELLGGPSVFLFPPKPK DTLMISRTPE VTCVVVDVSH EDPEVKFNWY VDGVEVHNAK TKPREEQYNS TYRVVSVLTV LHQDWLNGKE YKCKVSNKAL PAPIEKTISK AKGQPREPQV YTLPPSRDEL TKNQVSLTCL VKGFYPSDIA VEWESNGQPE NNYKTTPPVL DSDGSFFLYS KLTVDKSRWQQGNVFSCSVM HEALHNHYTQ KSLSLSPGKH HHHHH
Biological Activity:Measured in a neutralizing assay using Jurkat human T lymphocyte. The ED50 for this effect is less or equal to 10 ng/ml in the presence of 2ng/ml TRAIL. 

TRAIL Receptor-4 Human Recombinant or TNFRSF10D, is part of the TNF-receptor superfamily. TNFRSF10D has atruncated cytoplasmic death domai , an extracellular TRAIL-binding domain and a transmembrane domain. The protein can prevent from TRAIL-mediated apoptosis on cells with TRAIL R1 and/or TRAIL R2.

TNFRSF10D produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 395 amino acids (56-211a.a.) and having a molecular mass of 73.8kDa. (Molecular size on SDS-PAGE will appear at approximately 40-57kDa).TNFRSF10D is expressed with a 239 amino acid hIgG-His tag at C-Terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:TRAIL-R4: Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF- kappa-B pathway. According to PubMed:9382840, it cannot but according to PubMed:9430226, it can induce the NF-kappa-B pathway. Widely expressed, in particular in fetal kidney, lung and liver, and in adult testis and liver. Also expressed in peripheral blood leukocytes, colon and small intestine, ovary, prostate, thymus, spleen, pancreas, kidney, lung, placenta and heart.
UniProt Protein Details:

Protein type:Membrane protein, integral

Chromosomal Location of Human Ortholog: 8p21

Cellular Component: integral to membrane

Molecular Function:transmembrane receptor activity; TRAIL binding

Biological Process: apoptosis; signal transduction; negative regulation of apoptosis

NCBI Summary:The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain, a transmembrane domain, and a truncated cytoplamic death domain. This receptor does not induce apoptosis, and has been shown to play an inhibitory role in TRAIL-induced cell apoptosis. [provided by RefSeq, Jul 2008]
UniProt Code:Q9UBN6
NCBI GenInfo Identifier:18203495
NCBI Gene ID:8793
NCBI Accession:Q9UBN6.1
UniProt Secondary Accession:Q9UBN6,Q9Y6Q4, B2R8W0,
UniProt Related Accession:Q9UBN6
Molecular Weight:41,823 Da
NCBI Full Name:Tumor necrosis factor receptor superfamily member 10D
NCBI Synonym Full Names:tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
NCBI Official Symbol:TNFRSF10D  
NCBI Official Synonym Symbols:DCR2; CD264; TRUNDD; TRAILR4; TRAIL-R4  
NCBI Protein Information:tumor necrosis factor receptor superfamily member 10D; TRAIL receptor 4; decoy receptor 2; TNF receptor-related receptor for TRAIL; TRAIL receptor with a truncated death domain; TNF-related apoptosis-inducing ligand receptor 4
UniProt Protein Name:Tumor necrosis factor receptor superfamily member 10D
UniProt Synonym Protein Names:Decoy receptor 2; DcR2; TNF-related apoptosis-inducing ligand receptor 4; TRAIL receptor 4; TRAIL-R4; TRAIL receptor with a truncated death domain; CD_antigen: CD264
Protein Family:Tumor necrosis factor receptor superfamily
UniProt Gene Name:TNFRSF10D  
UniProt Entry Name:TR10D_HUMAN
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