Human TGFB1/TGF-beta 1 Recombinant Protein (RPES1385)

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SKU:
RPES1385
Product type:
Recombinant Protein
Host species:
Human Cells
Reactivity:
Human
Frequently bought together:

Description

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Human TGFB1/TGF-beta 1 Recombinant Protein

Transforming Growth Factor β-1 (TGFβ-1) is a secreted protein which belongs to the TGF-β family. TGFβ-1 is abundantly expressed in bone; articular cartilage and chondrocytes and is increased in osteoarthritis (OA). TGFβ-1 performs many cellular functions; including the control of cell growth; cell proliferation; cell differentiation and apoptosis. The precursor is cleaved into a latency-associated peptide (LAP) and a mature TGFβ-1 peptide. TGFβ-1 may also form heterodimers with other TGFβ family members. It has been found that TGFβ-1 is frequently upregulated in tumor cells. Mutations in this gene results in Camurati-Engelmann disease.

Product Name:Human TGFB1/TGF-beta 1 Recombinant Protein (RPES1385)
Product Code:RPES1385
Size:10µg
Species:Human
Expressed Host:Human Cells
Synonyms:Transforming Growth Factor Beta-1, TGF-Beta-1, Latency-Associated Peptide, LAP, TGFB1, TGFB,CED,DPD1,TGF-beta 1
Accession:P01137
Sequence:Ala279-Ser390
Fusion tag:
Activity:Measured by its ability to inhibit the IL-4-dependent proliferation of TF-1 mouse T cells.  The ED50 for this effect is 0.04-0.2 ng/ml
Endotoxin:<1.0 EU per µg as determined by the LAL method.
Protein Construction:Recombinant Human Transforming Growth Factor beta 1 is produced by our Mammalian expression system and the target gene encoding Ala279-Ser390 is expressed.
Purity:> 95 % as determined by reducing SDS-PAGE.
Mol Mass:12.8 kDa
AP Mol Mass:13 kDa
Formulation:Lyophilized from a 0.2 µm filtered solution of 50mM Glycine; 50mM NaCl; pH4.0.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

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