Human TFPI2 Recombinant Protein (RPPB4939)

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SKU:
RPPB4939
Product type:
Recombinant Protein
Size:
5ug
Species:
Human
Target:
TFPI2
Synonyms:
Tissue Factor Pathway Inhibitor 2
Synonyms:
Placental Protein 5
Synonyms:
TFPI-2
Synonyms:
PP5
Source:
Sf9 Insect cells
Uniprot:
P48307
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Description

Product Name:Human TFPI2 Recombinant Protein
Product Code:RPPB4939
Size:5µg
Species:Human
Target:TFPI2
Synonyms:Tissue Factor Pathway Inhibitor 2, Placental Protein 5, TFPI-2, PP5, Retinal Pigment Epithelium Cell Factor 1, REF1, TFPI2.
Source:Sf9 Insect cells
Physical Appearance:Sterile filtered colorless solution.
Formulation:TFPI2 protein solution (0.5mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:DAAQEPTGNN AEICLLPLDY GPCRALLLRY YYDRYTQSCR QFLYGGCEGN ANNFYTWEAC DDACWRIEKV PKVCRLQVSV DDQCEGSTEK YFFNLSSMTC EKFFSGGCHR NRIENRFPDE ATCMGFCAPK KIPSFCYSPK DEGLCSANVT RYYFNPRYRT CDAFTYTGCG GNDNNFVSRE DCKRACAKAL KLEHHHHHH

TFPI2 takes part in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa. TFPI2 doesn’t have any influence on thrombin.

TFPI2 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 199 amino acids (23-213 a.a.) and having a molecular mass of 22.9kDa (Migrates at 18-40kDa on SDS-PAGE under reducing conditions).TFPI2 is expressed with an 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:TFPI2: May play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa. Has no effect on thrombin.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 7q22

Cellular Component: proteinaceous extracellular matrix; nucleus

Molecular Function:serine-type endopeptidase inhibitor activity; extracellular matrix structural constituent

Biological Process: blood coagulation

NCBI Summary:This gene encodes a member of the Kunitz-type serine proteinase inhibitor family. The protein can inhibit a variety of serine proteases including factor VIIa/tissue factor, factor Xa, plasmin, trypsin, chymotryspin and plasma kallikrein. This gene has been identified as a tumor suppressor gene in several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
UniProt Code:P48307
NCBI GenInfo Identifier:1351226
NCBI Gene ID:7980
NCBI Accession:P48307.1
UniProt Secondary Accession:P48307,Q66ME8, Q8NAK6, Q9UC86,
UniProt Related Accession:P48307
Molecular Weight:25,796 Da
NCBI Full Name:Tissue factor pathway inhibitor 2
NCBI Synonym Full Names:tissue factor pathway inhibitor 2
NCBI Official Symbol:TFPI2  
NCBI Official Synonym Symbols:PP5; REF1; TFPI-2  
NCBI Protein Information:tissue factor pathway inhibitor 2; placental protein 5; retinal pigment epithelium cell factor 1
UniProt Protein Name:Tissue factor pathway inhibitor 2
UniProt Synonym Protein Names:Placental protein 5; PP5
Protein Family:Tissue factor pathway inhibitor
UniProt Gene Name:TFPI2  
UniProt Entry Name:TFPI2_HUMAN
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