Human TFF2 Recombinant Protein (RPPB0963)

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SKU:
RPPB0963
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
TFF2
Synonyms:
TFF-2
Synonyms:
Spasmolytic polypeptide
Synonyms:
Spasmolysin
Synonyms:
SML1
Source:
Escherichia Coli
Uniprot:
Q03403
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Description

Product Name:Human TFF2 Recombinant Protein
Product Code:RPPB0963
Size:20µg
Species:Human
Target:TFF2
Synonyms:TFF-2, Spasmolytic polypeptide, Spasmolysin, SML1, Trefoil factor 2, SP, TFF2.
Source:Escherichia Coli
Physical Appearance:Filtered White lyophilized (freeze-dried) powder.
Formulation:The TFF2 protein was lyophilized from 0.4?m filtered solution at a concentration of 0.5mg/ml containing 20mM Tris pH-7.5, and 20mM NaCl.
Solubility:It is recommended to add deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.
Stability:Lyophilized TFF2 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution TFF2 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MKHHHHHHAS EKPSPCQCSR LSPHNRTNCG FPGITSDQCF DNGCCFDSSV TGVPWCFHPL PKQESDQCVM EVSDRRNCGY PGISPEECAS RKCCFSNFIF EVPWCFFPKSVEDCHY

Proteins of the TFF family are characterized by obtaining a minimum of 1 copy of the trefoil motif, a 40-amino acid domain that contains 3 conserved disulfides. Trefoil Factors are stable secretory proteins expressed in gastrointestinal mucosa which protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium.TFF2 inhibits gastric acid motility & secretion. TFF2 stabilizes glycoproteins in the mucus gel through interactions with carbohydrate side chains.

TFF-2 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 116 amino acids (24-129) which includes a 10 amino acid His Tag fused at N-terminus and having a total molecular mass of 13.2 kDa. TFF2 Human Recombinant is purified by proprietary chromatographic techniques.

UniProt Protein Function:TFF2: Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: extracellular space

Molecular Function:protein binding

Biological Process: digestion; wound healing

NCBI Summary:Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. The encoded protein inhibits gastric acid secretion. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008]
UniProt Code:Q03403
NCBI GenInfo Identifier:2833194
NCBI Gene ID:7032
NCBI Accession:Q03403.2
UniProt Secondary Accession:Q03403,Q15854,
UniProt Related Accession:Q03403
Molecular Weight:14,284 Da
NCBI Full Name:Trefoil factor 2
NCBI Synonym Full Names:trefoil factor 2
NCBI Official Symbol:TFF2  
NCBI Official Synonym Symbols:SP; SML1  
NCBI Protein Information:trefoil factor 2
UniProt Protein Name:Trefoil factor 2
UniProt Synonym Protein Names:Spasmolysin; Spasmolytic polypeptide; SP
Protein Family:Splenin
UniProt Gene Name:TFF2  
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