Human TDO2 Recombinant Protein (RPPB2309)

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SKU:
RPPB2309
Product type:
Recombinant Protein
Size:
5ug
Species:
Human
Target:
TDO2
Synonyms:
Tryptophan 2
Synonyms:
3-dioxygenase
Synonyms:
TDO
Synonyms:
Tryptamin 2
Source:
Escherichia Coli
Uniprot:
P48775
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Description

Product Name:Human TDO2 Recombinant Protein
Product Code:RPPB2309
Size:5µg
Species:Human
Target:TDO2
Synonyms:Tryptophan 2,3-dioxygenase, TDO, Tryptamin 2,3-dioxygenase, Tryptophan oxygenase, TO, TRPO, Tryptophan pyrrolase, Tryptophanase, TDO2, TPH2.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The TDO2 solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 0.2M NaCl, 5mM DTT, 1mM EDTA and 30% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MSGCPFLGNN FGYTFKKLPV EGSEEDKSQT GVNRASKGGL IYGNYLHLEK VLNAQELQSE TKGNKIHDEH LFIITHQAYE LWFKQILWEL DSVREIFQNG HVRDERNMLK VVSRMHRVSV ILKLLVQQFS ILETMTALDF NDFREYLSPA SGFQSLQFRL LENKIGVLQN MRVPYNRRHY RDNFKGEENE LLLKSEQEKT LLELVEAWLE RTPGLEPHGF NFWGKLEKNI TRGLEEEFIR IQAKEESEEK EEQVAEFQKQ KEVLLSLFDE KRHEHLLSKG ERRLSYRALQ GALMIYFYRE EPRFQVPFQL LTSLMDIDSL MTKWRYNHVC MVHRMLGSKA GTGGSSGYHY LRSTVSDRYK VFVDLFNLST YLIPRHWIPK MNPTIHKFLY TAEYCDSSYF SSDESD

TDO2 is a ferrous heme enzyme that catalyzes the first and rate-limiting step in the kynurenine pathway which is the major pathway of tryptophan metabolism. TDO2 integrates oxygen into the indole moiety of tryptophan. TDO2 has broad specificity towards tryptamine and derivatives including D- and L-tryptophan, 5-hydroxytryptophan and serotonin.

TDO2 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 426 amino acids (1-406 a.a.) and having a molecular mass of 50kDa. The TDO2 is purified by proprietary chromatographic techniques.

UniProt Protein Function:TDO2: Incorporates oxygen into the indole moiety of tryptophan. Has a broad specificity towards tryptamine and derivatives including D- and L-tryptophan, 5-hydroxytryptophan and serotonin. Belongs to the tryptophan 2,3-dioxygenase family.
UniProt Protein Details:

Protein type:Amino Acid Metabolism - tryptophan; Oxidoreductase; EC 1.13.11.11

Chromosomal Location of Human Ortholog: 4q31-q32

Cellular Component: cytosol

Molecular Function:heme binding; protein binding; tryptophan 2,3-dioxygenase activity

Biological Process: tryptophan catabolic process; tryptophan catabolic process to acetyl-CoA

NCBI Summary:This gene encodes a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism. [provided by RefSeq, Feb 2012]
UniProt Code:P48775
NCBI GenInfo Identifier:1351188
NCBI Gene ID:6999
NCBI Accession:P48775.1
UniProt Secondary Accession:P48775,A8K053,
UniProt Related Accession:P48775
Molecular Weight:47,872 Da
NCBI Full Name:Tryptophan 2,3-dioxygenase
NCBI Synonym Full Names:tryptophan 2,3-dioxygenase
NCBI Official Symbol:TDO2  
NCBI Official Synonym Symbols:TO; TDO; TPH2; TRPO  
NCBI Protein Information:tryptophan 2,3-dioxygenase
UniProt Protein Name:Tryptophan 2,3-dioxygenase
UniProt Synonym Protein Names:Tryptamin 2,3-dioxygenase
UniProt Gene Name:TDO2  
UniProt Entry Name:T23O_HUMAN
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