Human TBCB Recombinant Protein (RPPB4915)
- SKU:
- RPPB4915
- Product type:
- Recombinant Protein
- Size:
- 25ug
- Species:
- Human
- Target:
- TBCB
- Synonyms:
- Tubulin folding cofactor B
- Cytoskeleton-associated protein CKAPI
- cytoskeleton associated protein 1
- CKAP1
- Source:
- Escherichia Coli
- Uniprot:
- Q99426
Description
| Product Name: | Human TBCB Recombinant Protein |
| Product Code: | RPPB4915 |
| Size: | 25µg |
| Species: | Human |
| Target: | TBCB |
| Synonyms: | Tubulin folding cofactor B, Cytoskeleton-associated protein CKAPI, cytoskeleton associated protein 1, CKAP1, CG22, Tubulin-specific chaperone B. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The TBCB solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 100mM Nacl and 20% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMEVTGV SAPTVTVFIS SSLNTFRSEK RYSRSLTIAE FKCKLELLVG SPASCMELEL YGVDDKFYSK LDQEDALLGS YPVDDGCRIH VIDHSGARLG EYEDVSRVEK YTISQEAYDQ RQDTVRSFLK RSKLGRYNEE ERAQQEAEAA QRLAEEKAQA SSIPVGSRCE VRAAGQSPRR GTVMYVGLTD FKPGYWIGVR YDEPLGKNDG SVNGKRYFEC QAKYGAFVKP AVVTVGDFPE EDYGLDEI |
TBCB is a member of the Microtubules family. Biosynthesis of functional microtubules include the involvement of a number of chaperones, termed Tubulin folding cofactors A (TBCA), B (TBCB), C (TBCC), D (TBCD) and E (TBCE), which operate on folding intermediates downstream of the cytosolic chaperon, known as TCP. The 244 amino acid cytoplasmic protein TBCB has one CAP-Gly domain and is universally expressed. TBCB takes part in the regulation of tubulin heterodimer dissociation and operates as a negative regulator of axonal growth.
TBCB Human Recombinant produced in E. coli is a single polypeptide chain containing 268 amino acids (1-244) and having a molecular mass of 29.9 kDa.TBCB is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | TBCB: a cytoskeletal protein that binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Chaperone; Cytoskeletal Chromosomal Location of Human Ortholog: 19q13.11-q13.12 Cellular Component: microtubule cytoskeleton; nucleoplasm; microtubule; cytoplasm Molecular Function:protein binding Biological Process: nervous system development; 'de novo' posttranslational protein folding; cellular protein metabolic process; cell differentiation |
| UniProt Code: | Q99426 |
| NCBI GenInfo Identifier: | 3023518 |
| NCBI Gene ID: | 1155 |
| NCBI Accession: | Q99426.2 |
| UniProt Secondary Accession: | Q99426,O00111, O00674, O14728, Q6FGY5, |
| UniProt Related Accession: | Q99426 |
| Molecular Weight: | 244 |
| NCBI Full Name: | Tubulin-folding cofactor B |
| NCBI Synonym Full Names: | tubulin folding cofactor B |
| NCBI Official Symbol: | TBCB |
| NCBI Official Synonym Symbols: | CG22; CKAP1; CKAPI |
| NCBI Protein Information: | tubulin-folding cofactor B; tubulin-specific chaperone B; cytoskeleton associated protein 1; cytoskeleton-associated protein CKAPI |
| UniProt Protein Name: | Tubulin-folding cofactor B |
| UniProt Synonym Protein Names: | Cytoskeleton-associated protein 1; Cytoskeleton-associated protein CKAPI; Tubulin-specific chaperone B |
| UniProt Gene Name: | TBCB |
| UniProt Entry Name: | TBCB_HUMAN |
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