Human TBCB Recombinant Protein (RPPB4915)

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SKU:
RPPB4915
Product type:
Recombinant Protein
Size:
25ug
Species:
Human
Target:
TBCB
Synonyms:
Tubulin folding cofactor B
Synonyms:
Cytoskeleton-associated protein CKAPI
Synonyms:
cytoskeleton associated protein 1
Synonyms:
CKAP1
Source:
Escherichia Coli
Uniprot:
Q99426
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Description

Product Name:Human TBCB Recombinant Protein
Product Code:RPPB4915
Size:25µg
Species:Human
Target:TBCB
Synonyms:Tubulin folding cofactor B, Cytoskeleton-associated protein CKAPI, cytoskeleton associated protein 1, CKAP1, CG22, Tubulin-specific chaperone B.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The TBCB solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 100mM Nacl and 20% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSHMEVTGV SAPTVTVFIS SSLNTFRSEK RYSRSLTIAE FKCKLELLVG SPASCMELEL YGVDDKFYSK LDQEDALLGS YPVDDGCRIH VIDHSGARLG EYEDVSRVEK YTISQEAYDQ RQDTVRSFLK RSKLGRYNEE ERAQQEAEAA QRLAEEKAQA SSIPVGSRCE VRAAGQSPRR GTVMYVGLTD FKPGYWIGVR YDEPLGKNDG SVNGKRYFEC QAKYGAFVKP AVVTVGDFPE EDYGLDEI

TBCB is a member of the Microtubules family. Biosynthesis of functional microtubules include the involvement of a number of chaperones, termed Tubulin folding cofactors A (TBCA), B (TBCB), C (TBCC), D (TBCD) and E (TBCE), which operate on folding intermediates downstream of the cytosolic chaperon, known as TCP. The 244 amino acid cytoplasmic protein TBCB has one CAP-Gly domain and is universally expressed. TBCB takes part in the regulation of tubulin heterodimer dissociation and operates as a negative regulator of axonal growth.

TBCB Human Recombinant produced in E. coli is a single polypeptide chain containing 268 amino acids (1-244) and having a molecular mass of 29.9 kDa.TBCB is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:TBCB: a cytoskeletal protein that binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Chaperone; Cytoskeletal

Chromosomal Location of Human Ortholog: 19q13.11-q13.12

Cellular Component: microtubule cytoskeleton; nucleoplasm; microtubule; cytoplasm

Molecular Function:protein binding

Biological Process: nervous system development; 'de novo' posttranslational protein folding; cellular protein metabolic process; cell differentiation

UniProt Code:Q99426
NCBI GenInfo Identifier:3023518
NCBI Gene ID:1155
NCBI Accession:Q99426.2
UniProt Secondary Accession:Q99426,O00111, O00674, O14728, Q6FGY5,
UniProt Related Accession:Q99426
Molecular Weight:244
NCBI Full Name:Tubulin-folding cofactor B
NCBI Synonym Full Names:tubulin folding cofactor B
NCBI Official Symbol:TBCB  
NCBI Official Synonym Symbols:CG22; CKAP1; CKAPI  
NCBI Protein Information:tubulin-folding cofactor B; tubulin-specific chaperone B; cytoskeleton associated protein 1; cytoskeleton-associated protein CKAPI
UniProt Protein Name:Tubulin-folding cofactor B
UniProt Synonym Protein Names:Cytoskeleton-associated protein 1; Cytoskeleton-associated protein CKAPI; Tubulin-specific chaperone B
UniProt Gene Name:TBCB  
UniProt Entry Name:TBCB_HUMAN
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