Human TBCA Recombinant Protein (RPPB4914)

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SKU:
RPPB4914
Product type:
Recombinant Protein
Size:
25ug
Species:
Human
Target:
TBCA
Synonyms:
Tubulin-specific chaperone A
Synonyms:
Tubulin-folding cofactor A
Synonyms:
CFA
Synonyms:
TCP1-chaperonin cofactor A
Source:
Escherichia Coli
Uniprot:
O75347
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Description

Product Name:Human TBCA Recombinant Protein
Product Code:RPPB4914
Size:25µg
Species:Human
Target:TBCA
Synonyms:Tubulin-specific chaperone A, Tubulin-folding cofactor A, CFA, TCP1-chaperonin cofactor A, TBCA.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The TBCA solution contains 20mM Tris-HCl buffer pH 7.5, 1mM DTT and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MADPRVRQIK IKTGVVKRLV KEKVMYEKEA KQQEEKIEKM RAEDGENYDI KKQAEILQES RMMIPDCQRR LEAAYLDLQR ILENEKDLEE AEEYKEARLV LDSVKLEA

TBCA is a tubulin-folding protein which is involved in the early step of the tubulin folding pathway. TBCA is one of four proteins (cofactors A, D, E, and C) implicated in the pathway directing to properly folded beta-tubulin from folding intermediates. Cofactors A and D are thought to be a factor in capturing and stabilizing beta-tubulin in a quasi-native confirmation. TBCA is crucial for cell viability, if reduced it causes a decrease in the amount of soluble tubulin, alterations in microtubules and G1 cell cycle arrest. Cofactor E attaches to the cofactor D-tubulin complex, afterward, interaction with cofactor C triggers the release of tubulin polypeptides that are committed to the native state.

TBCA Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 108 amino acids (1-108 a.a.) and having a molecular mass of 12.8 kDa.The TBCA is purified by proprietary chromatographic techniques.

UniProt Protein Function:TBCA: Tubulin-folding protein; involved in the early step of the tubulin folding pathway. Belongs to the TBCA family.
UniProt Protein Details:

Protein type:Chaperone

Chromosomal Location of Human Ortholog: 5q14.1

Cellular Component: microtubule cytoskeleton; microtubule; cytoplasm; nucleolus

Molecular Function:chaperone binding; unfolded protein binding

Biological Process: tubulin folding; 'de novo' posttranslational protein folding; cellular protein metabolic process; protein folding; post-chaperonin tubulin folding pathway

NCBI Summary:The product of this gene is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. This gene encodes chaperonin cofactor A. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
UniProt Code:O75347
NCBI GenInfo Identifier:6831691
NCBI Gene ID:6902
NCBI Accession:O75347.3
UniProt Related Accession:O75347
Molecular Weight:12,855 Da
NCBI Full Name:Tubulin-specific chaperone A
NCBI Synonym Full Names:tubulin folding cofactor A
NCBI Official Symbol:TBCA  
NCBI Protein Information:tubulin-specific chaperone A; CFA; chaperonin cofactor A; TCP1-chaperonin cofactor A; tubulin-folding cofactor A
UniProt Protein Name:Tubulin-specific chaperone A
UniProt Synonym Protein Names:TCP1-chaperonin cofactor A; Tubulin-folding cofactor A; CFA
UniProt Gene Name:TBCA  
UniProt Entry Name:TBCA_HUMAN
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