Human TBCA Recombinant Protein (RPPB4914)
- SKU:
- RPPB4914
- Product type:
- Recombinant Protein
- Size:
- 25ug
- Species:
- Human
- Target:
- TBCA
- Synonyms:
- Tubulin-specific chaperone A
- Tubulin-folding cofactor A
- CFA
- TCP1-chaperonin cofactor A
- Source:
- Escherichia Coli
- Uniprot:
- O75347
Description
| Product Name: | Human TBCA Recombinant Protein |
| Product Code: | RPPB4914 |
| Size: | 25µg |
| Species: | Human |
| Target: | TBCA |
| Synonyms: | Tubulin-specific chaperone A, Tubulin-folding cofactor A, CFA, TCP1-chaperonin cofactor A, TBCA. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The TBCA solution contains 20mM Tris-HCl buffer pH 7.5, 1mM DTT and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MADPRVRQIK IKTGVVKRLV KEKVMYEKEA KQQEEKIEKM RAEDGENYDI KKQAEILQES RMMIPDCQRR LEAAYLDLQR ILENEKDLEE AEEYKEARLV LDSVKLEA |
TBCA is a tubulin-folding protein which is involved in the early step of the tubulin folding pathway. TBCA is one of four proteins (cofactors A, D, E, and C) implicated in the pathway directing to properly folded beta-tubulin from folding intermediates. Cofactors A and D are thought to be a factor in capturing and stabilizing beta-tubulin in a quasi-native confirmation. TBCA is crucial for cell viability, if reduced it causes a decrease in the amount of soluble tubulin, alterations in microtubules and G1 cell cycle arrest. Cofactor E attaches to the cofactor D-tubulin complex, afterward, interaction with cofactor C triggers the release of tubulin polypeptides that are committed to the native state.
TBCA Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 108 amino acids (1-108 a.a.) and having a molecular mass of 12.8 kDa.The TBCA is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | TBCA: Tubulin-folding protein; involved in the early step of the tubulin folding pathway. Belongs to the TBCA family. |
| UniProt Protein Details: | Protein type:Chaperone Chromosomal Location of Human Ortholog: 5q14.1 Cellular Component: microtubule cytoskeleton; microtubule; cytoplasm; nucleolus Molecular Function:chaperone binding; unfolded protein binding Biological Process: tubulin folding; 'de novo' posttranslational protein folding; cellular protein metabolic process; protein folding; post-chaperonin tubulin folding pathway |
| NCBI Summary: | The product of this gene is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. This gene encodes chaperonin cofactor A. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014] |
| UniProt Code: | O75347 |
| NCBI GenInfo Identifier: | 6831691 |
| NCBI Gene ID: | 6902 |
| NCBI Accession: | O75347.3 |
| UniProt Related Accession: | O75347 |
| Molecular Weight: | 12,855 Da |
| NCBI Full Name: | Tubulin-specific chaperone A |
| NCBI Synonym Full Names: | tubulin folding cofactor A |
| NCBI Official Symbol: | TBCA |
| NCBI Protein Information: | tubulin-specific chaperone A; CFA; chaperonin cofactor A; TCP1-chaperonin cofactor A; tubulin-folding cofactor A |
| UniProt Protein Name: | Tubulin-specific chaperone A |
| UniProt Synonym Protein Names: | TCP1-chaperonin cofactor A; Tubulin-folding cofactor A; CFA |
| UniProt Gene Name: | TBCA |
| UniProt Entry Name: | TBCA_HUMAN |
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