Human TAGLN Recombinant Protein (RPPB4901)

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SKU:
RPPB4901
Product type:
Recombinant Protein
Size:
25ug
Species:
Human
Target:
TAGLN
Synonyms:
SM22
Synonyms:
SMCC
Synonyms:
TAGLN1
Synonyms:
WS3-10
Source:
Escherichia Coli
Uniprot:
Q01995
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Description

Product Name:Human TAGLN Recombinant Protein
Product Code:RPPB4901
Size:25µg
Species:Human
Target:TAGLN
Synonyms:SM22, SMCC, TAGLN1, WS3-10, Transgelin, Smooth muscle protein 22-alpha, SM22-alpha, TAGLN, DKFZp686B01212, DKFZp686P11128.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:TAGLN Human solution containing 20mM Tris-HCl pH-7.5, 1mM DTT & 20% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MANKGPSYGM SREVQSKIEK KYDEELEERL VEWIIVQCGP DVGRPDRGRL GFQVWLKNGV ILSKLVNSLY PDGSKPVKVP ENPPSMVFKQ MEQVAQFLKA AEDYGVIKTD MFQTVDLFEG KDMAAVQRTL MALGSLAVTK NDGHYRGDPN WFMKKAQEHK REFTESQLQE GKHVIGLQMG SNRGASQAGM TGYGRPRQII S

TAGLN is a transformation and form-change responsive actin cross-linking/gelling protein that is part of the calponin family. TAGLN is expressed abundantly in fibroblasts and smooth muscle. TAGLN participates in calcium interactions and contractile properties of the cell that contribute to replicative senescence. Throughout embryogenesis, TAGLN is expressed in smooth, cardiac and skeletal muscle, but is limited during late fetal growth and adulthood to all vascular and visceral smooth muscle cells and low levels of expression in heart. TAGLN is downregulated in several transformed cell lines, showing that a decrease of TAGLN expression is an premature indicator of the onset of transformation.

TAGLN Recombinant E.coli produced in E.Coli is a single, non-glycosylated polypeptide chain containing 221 amino acids (1-201 a.a.) and having a molecular mass of 24.8 kDa. The TAGLN is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:TAGLN: Actin cross-linking/gelling protein. Involved in calcium interactions and contractile properties of the cell that may contribute to replicative senescence. Belongs to the calponin family.
UniProt Protein Details:

Protein type:Nuclear receptor co-regulator; Actin-binding; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 11q23.2

Molecular Function:protein binding

Biological Process: epithelial cell differentiation; muscle development

NCBI Summary:The protein encoded by this gene is a transformation and shape-change sensitive actin cross-linking/gelling protein found in fibroblasts and smooth muscle. Its expression is down-regulated in many cell lines, and this down-regulation may be an early and sensitive marker for the onset of transformation. A functional role of this protein is unclear. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:Q01995
NCBI GenInfo Identifier:3123283
NCBI Gene ID:6876
NCBI Accession:Q01995.4
UniProt Secondary Accession:Q01995,O15542,
UniProt Related Accession:Q01995
Molecular Weight:22,611 Da
NCBI Full Name:Transgelin
NCBI Synonym Full Names:transgelin
NCBI Official Symbol:TAGLN  
NCBI Official Synonym Symbols:SM22; SMCC; TAGLN1; WS3-10  
NCBI Protein Information:transgelin
UniProt Protein Name:Transgelin
UniProt Synonym Protein Names:22 kDa actin-binding protein; Protein WS3-10; Smooth muscle protein 22-alpha; SM22-alpha
Protein Family:Transgelin
UniProt Gene Name:TAGLN  
UniProt Entry Name:TAGL_HUMAN
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