Human TAF15 Recombinant Protein (RPPB4900)

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SKU:
RPPB4900
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
TAF15
Synonyms:
Npl3
Synonyms:
RBP56
Synonyms:
TAF2N
Synonyms:
TAFII68
Source:
Escherichia Coli
Uniprot:
Q92804
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Description

Product Name:Human TAF15 Recombinant Protein
Product Code:RPPB4900
Size:20µg
Species:Human
Target:TAF15
Synonyms:Npl3, RBP56, TAF2N, TAFII68, TATA-binding protein-associated factor 2N, 68 kDa TATA-binding protein-associated factor, RNA-binding protein 56, TAF15.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:The TAF15 solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 30% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSSYHSQRE NYSHHTQDDR RDVSRYGEDN RGYGGSQGGG RGRGGYDKDG RGPMTGSSGG DRGGFKNFGG HRDYGPRTDA DSESDNSDNN TIFVQGLGEG VSTDQVGEFF KQIGIIKTNK KTGKPMINLY TDKDTGKPKG EATVSFDDPP SAKAAIDWFD GKEFHGNIIK VSFATRRPEF MRGGGSGGGR RGRGGYRGRG GFQGRGGDPK SGDWVCPNPS CGNMNFARRN SCNQCNEPRP EDSRPSGGDF RGRGYGGERG YR

TAF15 is a member of the TET family of RNA-binding proteins. TAF15 is a component of a subset of multi-subunit transcription initiation factor TFIID complexes which takes part in RNA polymerase II gene transcription. Translocations involving TAF15 are found in severe leukemia and extraskeletal myxoid chondrosarcoma. Mutations in TAF15 take part in amyotrophic lateral sclerosis.

TAF15 Human Recombinant produced in E. coli is. a single polypeptide chain containing 282 amino acids (148-406) and having a molecular mass of 30kDa. TAF15 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:TAF15: RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters. Can enter the preinitiation complex together with the RNA polymerase II (Pol II). A chromosomal aberration involving TAF15/TAF2N is found in a form of extraskeletal myxoid chondrosarcomas (EMC). Translocation t(9;17)(q22;q11) with NR4A3. Belongs to the RRM TET family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:RNA-binding; Oncoprotein; Translation

Chromosomal Location of Human Ortholog: 17q11.1-q11.2

Cellular Component: cytoplasm; nucleolus; nucleoplasm; nucleus

Molecular Function:DNA binding; nucleotide binding; protein binding; zinc ion binding

Biological Process: positive regulation of transcription, DNA-dependent

Disease: Chondrosarcoma, Extraskeletal Myxoid

NCBI Summary:This gene encodes a member of the TET family of RNA-binding proteins. The encoded protein plays a role in RNA polymerase II gene transcription as a component of a distinct subset of multi-subunit transcription initiation factor TFIID complexes. Translocations involving this gene play a role in acute leukemia and extraskeletal myxoid chondrosarcoma, and mutations in this gene may play a role in amyotrophic lateral sclerosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
UniProt Code:Q92804
NCBI GenInfo Identifier:8928305
NCBI Gene ID:8148
NCBI Accession:Q92804.1
UniProt Secondary Accession:Q92804,Q86X94, Q92751, B2R837,
UniProt Related Accession:Q92804
Molecular Weight:61,558 Da
NCBI Full Name:TATA-binding protein-associated factor 2N
NCBI Synonym Full Names:TATA-box binding protein associated factor 15
NCBI Official Symbol:TAF15  
NCBI Official Synonym Symbols:Npl3; RBP56; TAF2N; TAFII68  
NCBI Protein Information:TATA-binding protein-associated factor 2N
UniProt Protein Name:TATA-binding protein-associated factor 2N
UniProt Synonym Protein Names:68 kDa TATA-binding protein-associated factor; TAF(II)68; TAFII68; RNA-binding protein 56
Protein Family:Transcription initiation factor
UniProt Gene Name:TAF15  
UniProt Entry Name:RBP56_HUMAN
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