Human TAC3 Recombinant Protein (RPPB4895)
- SKU:
- RPPB4895
- Product type:
- Recombinant Protein
- Size:
- 25ug
- Species:
- Human
- Target:
- TAC3
- Synonyms:
- Tachykinin-3
- ZNEUROK1
- Neurokinin-B
- NKB
- Source:
- Escherichia Coli
- Uniprot:
- Q9UHF0
Description
| Product Name: | Human TAC3 Recombinant Protein |
| Product Code: | RPPB4895 |
| Size: | 25µg |
| Species: | Human |
| Target: | TAC3 |
| Synonyms: | Tachykinin-3, ZNEUROK1, Neurokinin-B, NKB, Neuromedin-K, TAC3, NKNB, PRO1155. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The TAC3 solution contains 20mM Tris-HCl buffer (pH 8.0) and 20% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH QSFGAVCKEP QEEVVPGGGR SKRDPDLYQL LQRLFKSHSS LEGLLKALSQ ASTDPKESTS PEKRDMHDFF VGLMGKRSVQ PDSPTDVNQE NVPSFGILKY PPRAE |
Tachykinin-3 belongs to the substance P-related tachykinin family. Tachykinins are active peptides that stimulate neurons, induce behavioral responses, are effective vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. TAC3 and its receptor are essential switches of regulator of human puberty, regulated by the brain through the release of the GnRH which starts a chain of processes which eventually lead to the production of sex hormones. During pregnancy, the expression of TAC3 is restricted to the outer syncytiotrophoblast of the placenta, significant concentrations of TAC3 can be identified in plasma as early as week 9, and plasma concentrations of TAC3 are grossly elevated in pregnancy-induced hypertension and pre-eclampsia. Higher Tachykinin-3 concentrations in normotensive pregnant women may be caused by the advanced gestational age and/or the result of a negative interaction of other vasoactive substances. TAC3 has a role in the continuance of high placental blood flow in normal pregnancy.
TAC3 Human Recombinant fused with 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 125 amino acids (17-121 a.a.) and having a molecular mass of 13.8kDa.The TAC3 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | TAC3: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Belongs to the tachykinin family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 12q13.3 Cellular Component: extracellular region; extracellular space Molecular Function:receptor binding Biological Process: female pregnancy Disease: Hypogonadotropic Hypogonadism 10 With Or Without Anosmia |
| NCBI Summary: | This gene encodes a member of the tachykinin family of secreted neuropeptides. The encoded preproprotein is proteolytically processed to generate the mature peptide, which is primarily expressed in the central and peripheral nervous systems and functions as a neurotransmitter. This peptide is the ligand for the neurokinin-3 receptor. This protein is also expressed in the outer syncytiotrophoblast of the placenta and may be associated with pregnancy-induced hypertension and pre-eclampsia. Mutations in this gene are associated with normosmic hypogonadotropic hypogonadism. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016] |
| UniProt Code: | Q9UHF0 |
| NCBI GenInfo Identifier: | 18203501 |
| NCBI Gene ID: | 6866 |
| NCBI Accession: | Q9UHF0.1 |
| UniProt Secondary Accession: | Q9UHF0,Q6IAG2, Q71BC6, Q71BC9, |
| UniProt Related Accession: | Q9UHF0 |
| Molecular Weight: | 11,358 Da |
| NCBI Full Name: | Tachykinin-3 |
| NCBI Synonym Full Names: | tachykinin 3 |
| NCBI Official Symbol: | TAC3 |
| NCBI Official Synonym Symbols: | NKB; HH10; NKNB; PRO1155; ZNEUROK1 |
| NCBI Protein Information: | tachykinin-3 |
| UniProt Protein Name: | Tachykinin-3 |
| UniProt Synonym Protein Names: | ZNEUROK1 |
| Protein Family: | Tachykinin |
| UniProt Gene Name: | TAC3 |
| UniProt Entry Name: | TKNK_HUMAN |
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